谭仁祥  教授、博士生导师 

 办公地点:生科楼A413

 Email: rxtan@nju.edu.cn          返回


学习经历:


2001年1月-2001年11月:美国加州大学海洋研究院W. Fenical实验室访问教授。

1995年1月-1995年11月:瑞士洛桑大学药学院K. Hostettmann实验室访问教授。

1989年3月-1990年8月:德国柏林工业大学化学系完成博士论文,获博士学位(由兰州大学授予),导师:F. Bohlmann 教授。

1986年9月-1989年2月:兰州大学化学系天然有机化学方向的博士生。导师:朱子清、贾忠建教授。

1983年9月-1986年8月:中国药科大学天然药物化学方向的研究生,获硕士学位。

1979年9月-1983年8月:在中国药科大学药学系学习, 获学士学位。


工作经历:


2010年-:第十届国家药典委员会委员。

2002年2月-:南京大学校长助理。

2006年11月-2007年10月:南京大学医学院院长(代)。

2000年12月-:南京大学功能生物分子研究所所长(兼)。

1999年1月-2002年2月:南京大学生命科学学院副院长。

1999年11月:教育部“长江学者奖励计划”特聘教授。

1997年:获国家杰出青年基金。

1995年12月:南京大学博士生导师。

1994年4月:南京大学教授。


主持在研项目:


1. 海洋生物功能天然产物发掘、优化与合成【国家863计划海洋技术领域主题项目】。

2. 天然药源分子及其新作用特点【国家自然科学基金委创新研究群体科学基金,学术带头人,获两次滚动支持】。

3. 特境及不可培养微生物产生的新活性物质研究【国家自然科学基金重点项目】。

4. 调控Toll样受体的新共生菌产物研究【国家自然科学基金重大研究计划重点项目】。


获奖情况


2010年:谈家桢生命科学奖创新奖。

2009年:若干重要药用植物的成分研究. 国家自然科学奖二等奖。

2007年:Natural Product Reports Lecture Award (Royal Society of Chemistry, UK) 

2007年:植物内生真菌代谢物研究. 教育部提名国家科学技术奖(自然科学奖)一等奖。2005年:民间常用草药成分的分析与功能研究. 教育部提名国家科学技术奖(自然科学奖)一等奖。



学术兼职


英国皇家化学会会士(Fellow)

国家自然科学基金委员会专家咨询委员会委员

《Natural Product Reports》、《Current Medicinal Chemistry》等SCI刊物(顾问)编委。

曾任国际天然产物协会主席、《中国抗生素杂志》主编等职。


研究方向与主要贡献


长期从事天然产物化学研究,涉及植物和微生物来源的新活性分子的发现策略/方法、结构分析、功能鉴定和生物合成途径。已在《Nat. Commun.》、《Proc. Natl. Acad. Sci. USA》、《J. Am. Chem. Soc.》、《Angew. Chem. Int. Ed.》、《Chem. Rev.》等刊物上发表论文260多篇;主编《植物成分分析》、《植物成分功能》、《功能海洋生物分子——发现与应用》、《甾体化学》;取得授权发明专利26件。作为第一完成人,获2009年国家自然科学奖二等奖、2007年“Natural Product Reports Lecture Award”(英国皇家化学会,每年提名授奖一项)、2007年和2005年教育部一等奖等奖项。


代表性论文:


2022

1.       Wu, X.M.; Guan, Q.Y.; Han, Y.B.; Wang, X.C.; Zhuang, W.Y.; Tan, R.X.* Regeneration of Phytochemicals by Structure-Driven Organization of Microbial Biosynthetic Steps. Angew. Chem. Int. Ed. 2022, 61, e202114919.

2.       Qian, J.C.; Liu, D.; Lin, L.P.; Zhu, W.J.; Tan, R.X.* Minor bioactive indoles from kimchi mirror the regioselectivity in indole-3-carbinol oligomerization. Food Chem. 2022, 382, 132571.

3.       Lin, L.P.; Wu, M.; Jiang, N.; Wang, W.; Tan, R.X.* Carbon-nitrogen bond formation to construct novel polyketide-indole hybrids from the indole-3-carbinol exposed culture of Daldinia eschscholzii. Synth. Syst. Biotechnol. 2022, 7, 750-755.

4.       Wang, Y.S.; Zheng, W.; Jiang, N.; Jin, Y.X.; Meng, Z.K.; Sun, M.X.; Zong, Y.L.; Xu, T.; Zhu, J.P.; Tan, R.X.* Alteration of the Catalytic Reaction Trajectory of a Vicinal Oxygen Chelate Enzyme by Directed Evolution. Angew. Chem. Int. Ed. 2022, 61, e202201321.

5.       Lin, L.P.; Liu, D.; Qian, J.C.; Wu, L.; Zhao, Q.; Tan, R.X.* Post-ingestion conversion of dietary indoles into anticancer agents. Natl. Sci. Rev. 2022, 9, nwab144.

6.       Shi, J.; Shi, Y.; Li, J.C.; Wei, W.Q.; Chen, Y.; Cheng, P.; Li Liu, C.; Zhang, H.; Wu, R.; Zhang, B.; Jiao, R.H.; Yu, S.Y.; Liang, Y.; Tan, R.X.*; Ge, H.M.* In Vitro Reconstitution of Cinnamoyl Moiety Reveals Two Distinct Cyclases for Benzene Ring Formation. J. Am. Chem. Soc. 2022, 144, 7939-7948.

7.       Chen, Y.; Wei, Y.J.; Jiang, N.; Ge, H.M.; Jiao, R.H.; Cheng, X.; Tan, R.X.* Spirocitromycetin, a Fungal Polyketide with an Antiosteoporotic Pharmacophore. J. Nat. Prod. 2022, 85, 1442-1447.

8.       Liu, S.H.; Sun, J.L.; Hu, Y.L.; Zhang, L.; Zhang, X.; Yan, Z.Y.; Guo, X.; Guo, Z.K.; Jiao, R.H.; Zhang, B.; Tan, R.X.*; Ge, H.M.* Biosynthesis of Sordarin Revealing a Diels-Alderase for the Formation of the Norbornene Skeleton. Angew. Chem. Int. Ed. 2022, 61, e202205577.

9.       Zhou, B.B.; Liu, D.; Qian, J.C.; Tan, R.X.* Vegetable-derived indole enhances the melanoma-treating efficacy of chemotherapeutics. Phytother Res. 2022, 36, 4278-4292.

10.    Zhu, H.J.; Zhang, B.; Wei, W.Q.; Liu, S.H.; Xiang, L.; Zhu, J.P.; Jiao, R.H.; Igarashi, Y.; Bashiri, G.; Liang, Y.; Tan, R.X.*; Ge, H.M.* AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis. Nat. Commun. 2022, 13, 4499.

11.    Zhao, Y.; Zhang, B.; Sun, Z.Q.; Zhang, H.; Wang, W.; Wang, Z.R.; Guo, Z.K.; Yu, S.Y.; Tan, R.X.*; Ge, H.M.* Biocatalytic C14-Hydroxylation on Androstenedione Enabled Modular Synthesis of Cardiotonic Steroids. ACS Catal. 2022, 12, 9839-9845.

12.    Li, L.Y.; Hu, Y.L.; Sun, J.L.; Yu, L.B.; Shi, J.; Wang, Z.R.; Guo, Z.K.; Zhang, B.; Guo, W.J.; Tan, R.X.*; Ge, H.M.* Resistance and phylogeny guided discovery reveals structural novelty of tetracycline antibiotics. Chem. Sci. 2022, 13, 12892-12898.

13.    Song, Q.Q.; Lin, L.P.; Chen, Y.L.; Qian, J.C.; Wei, K.; Su, J.W.; Ding, J.H.; Lu, M.; Liu, Y.; Tan, R.X.*; Hu, G. Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway. Acta Pharmacol. Sin. 2022.

 

2021

14.    Bai, W.; Jing, L.L.; Guan, Q.Y.; Tan, R.X.* Two new azaphilone pigments from Talaromyces albobiverticillius and their anti-inflammatory activity. J Asian Nat Prod Res. 2021, 23, 325-332.

15.    Li, W.; Wei, L.; Chen, D.Y.; Wang, M.J.; Sun, Y.; Jiao, F.W.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410. Chin. J. Nat. Med. 2021, 18, 957-960.

16.    Li, X.Q.; Chen, Y.; Dai, G.C.; Zhou, B.B.; Yan, X.N.; Tan, R.X.* Abietic acid ameliorates psoriasis -like inflammation and modulates gut microbiota in mice. J Ethnopharmacol. 2021, 272, 113934.

17.    Shi, J.; Xu, X.; Liu, P.Y.; Hu, Y.L.; Zhang, B.; Jiao, R.H.; Bashiri, G.; Tan, R.X.*; Ge, H.M.* Discovery and biosynthesis of guanipiperazine from a NRPS-like pathway. Chem. Sci. 2021, 12, 2925-2930.

18.    Zhu, H.J.; Zhang, B.; Wang, L.; Wang, W.; Liu, S.H.; Igarashi, Y.; Bashiri, G.; Tan, R.X.*; Ge, H.M.* Redox Modifications in the Biosynthesis of Alchivemycin A Enable the Formation of Its Key Pharmacophore. J. Am. Chem. Soc. 2021, 143, 4751-4757.

19.    Liu, D.; Jiang, N.; Huang, W.D.; Li, J.W.; Zhu, W.J.; Tan, R.X.* Ionic-Liquid-Catalyzed Access to CTr: An Antitumor Agent. ACS Sustain. Chem. Eng. 2021, 9, 5138-5147.

20.    Wang, K.B.; Wang, W.; Zhang, B.; Wang, X.; Chen, Y.; Zhu, H.J.; Liang, Y.; Tan, R.X.*; Ge, H.M.* A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis. Nat. Commun. 2021, 12, 2092.

21.    Zhu, W.J.; Lin, L.P.; Liu, D.; Qian, J.C.; Zhou, B.B.; Yuan, D.D.; Tan, R.X.* Pharmacophore-inspired discovery of FLT3 inhibitor from kimchi. Food Chem. 2021, 361, 130139.

22.    Lv, X.J.; Ding, F.; Wei, Y.J.; Tan, R.X.* Antiosteoporotic Tetrahydroxanthone Dimers from Aspergillus brunneoviolaceus FB-2 Residing in Human Gut. Chinese J. Chem. 2021, 39, 1580-1586.

23.    Tong, Z.W.; Xie, X.H.; Wang, T.T.; Lu, M.; Jiao, R.H.; Ge, H.M.; Hu, G.; Tan, R.X.* Acautalides A-C, Neuroprotective Diels-Alder Adducts from Solid-State Cultivated Acaulium sp. H-JQSF. Org. Lett. 2021, 23, 5587-5591.

24.    Wu, X.M.; Dai, G.C.; Zhou, B.B.; Chen, Y.; Tan, R.X.* Three new polyketide derivatives of the endophytic fungus Aspergillus cristatus 2H1. J Asian Nat Prod Res. 2021, 24, 722-730.

25.    Jiao, F.W.; Wang, Y.S.; You, X.T.; Wei, W.Q.; Chen, Y.; Yang, C.L.; Guo, Z.K.; Zhang, B.; Liang, Y.; Tan, R.X.*; Jiao, R.H.*; Ge, H.M.* An NADPH-Dependent Ketoreductase Catalyses the Tetracyclic to Pentacyclic Skeletal Rearrangement in Chartreusin Biosynthesis. Angew. Chem. Int. Ed. 2021, 60, 26378-26384.

 

2020

26.     Dai, G.Z.; Han, W.B.; Mei, Y.N.; Xu, K.; Jiao, R.H.; Ge, H.M.*; Tan, R.X.* Pyridoxal-5 ‘-phosphate dependent bifunctional enzyme catalyzed biosynthesis of indolizidine alkaloids in fungi. PNAS. 2020, 117, 1174-1180.

27.    Xu, Z.F.; Bo, S.T.; Wang, M.J.; Shi, J.; Jiao, R.H.; Sun, Y.; Xu, Q.; Tan, R.X.*; Ge, H.M.* Discovery and biosynthesis of bosamycins from Streptomyces sp. 120454. Chem. Sci. 2020, 11, 9237-9245.

28.    Li, W.; Jiao, F.W.; Wang, J.Q.; Shi, J.; Wang, T.T.; Khan, S.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Unguisin G, a new kynurenine-containing cyclic heptapeptide from the sponge-associated fungus Aspergillus candidus NF2412. Tetrahedron Lett. 2020, 61, 152322.

 

2019

29.    Zhang, L.; Luo, X.P.; Tan, R.X.* Effect of Light-Cured Resin Cement Application on Translucency of Ceramic Veneers and Light Transmission of LED Polymerization Units. J. Prosthodont. 2019, 28, E376-E382.

30.    Zhou, Z.Z.; Zhu, H.J.; Lin, L.P.; Zhang, X.; Ge, H.M.; Jiao, R.H.; Tan, R.X.* Dalmanol biosyntheses require coupling of two separate polyketide gene clusters. Chem. Sci. 2019, 10, 73-82.

31.    Lin, L.P.; Jiang, N.; Wu, H.M.; Mei, Y.N.; Yang, J.; Tan, R.X.* Cytotoxic and antibacterial polyketide-indole hybrids synthesized from indole-3-carbinol by Daldinia eschscholzii. Acta Pharm. Sin. B. 2019, 9, 369-380.

32.    Shi, J.; Zeng, Y.J.; Zhang, B.; Shao, F.L.; Chen, Y.C.; Xu, X.; Sun, Y.; Xu, Q.; Tan, R.X.*; Ge, H.M.* Comparative genome mining and heterologous expression of an orphan NRPS gene cluster direct the production of ashimides. Chem. Sci. 2019, 10, 3042-3048.

33.    Yang, C.L.; Wu, H.M.; Liu, C.L.; Zhang, X.; Guo, Z.K.; Chen, Y.; Liu, F.; Liang, Y.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Bialternacins A-F, Aromatic Polyketide Dimers from an Endophytic Alternaria sp. J. Nat. Prod. 2019, 82, 792-797.

34.    Zhang, B.; Wang, K.B.; Wang, W.; Wang, X.; Liu, F.; Zhu, J.P.; Shi, J.; Li, L.Y.; Han, H.; Xu, K.; Qiao, H.Y.; Zhang, X.; Jiao, R.H.; Houk, K.N.; Liang, Y.; Tan, R.X.*; Ge, H.M.* Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products. Nature. 2019, 568, 122–126.

35.    Wu, X.M.; Tan, R.X.* Interaction between gut microbiota and ethnomedicine constituents. Nat. Prod. Rep. 2019, 36, 788-809.

36.    Shi, J.; Liu, C.L.; Zhang, B.; Guo, W.J.; Zhu, J.P.; Chang, C.Y.; Zhao, E.J.; Jiao, R.H. Tan, R.X.*; Ge, H.M.* Genome mining and biosynthesis of kitacinnamycins as a STING activator. Chem. Sci. 2019, 10, 4839-4846.

37.    Liu, S.H.; Wang, W.; Wang, K.B.; Zhang, B.; Li, W.; Shi, J.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Heterologous Expression of a Cryptic Giant Type I PKS Gene Cluster Leads

38.    to the Production of Ansaseomycin. Org. Lett. 2019, 21, 3785-3788.

39.    Zhou, Z.Z.; Zhu, H.J.; Yang, C.L.; Liu, Y.J.; Jiang, N.; Xiao, Y.S.; Shi, L.Y.; Jiao, R.H.; Ge, H.M.*; Tan, R.X.* Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene. Chin. J. Nat. Med. 2019, 17, 387-393.

40.    Han, H.; Guo, Z.K.; Zhang, B.; Zhang, M.; Shi, J.; Li, W.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Bioactive phenazines from an earwig-associated Streptomyces sp. Chin. J. Nat. Med. 2019, 17, 475-480.

41.    Shen, L.; Ai, C.Z.; Song, Y.C.; Wang, F.W.; Jiao, R.H.; Zhang, A.H.; Man, H.Z.; Tan, R.X.* Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum. J. Nat. Prod. 2019, 82, 1503-1509.

42.    Yan, W.; Zhao, S.S.; Ye, Y.H.; Zhang, Y.Y.; Zhang, Y.; Xu, J.Y.; Yin, S.M.; Tan, R.X.*Generation of lndoles with Agrochemical Significance through Biotransformation by Chaetomium globosum. J. Nat. Prod. 2019, 82, 2132-2137.

43.    Shi, J.; Xu, X.; Zhao, E.J.; Zhang, B.; Li, W.; Zhao, Y.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Genome Mining and Enzymatic Total Biosynthesis of Purincyclamide. Org. Lett. 2019,21, 6825-6829.

44.    Zhang, A.H.; Jiang, N.; Wang, X.Q.; Tan, R.X.* Galewone, an Anti-Fibrotic Polyketide from Daldinia eschscholzii with an Undescribed Carbon Skeleton. Sci. Rep. 2019, 9, 14316.

45.    Li, X.Q.; Chen, Y.; Zhou, H.M.; Shi, H.L.; Yan, X.N.; Lin, L.P.; Tan, R.X.* Anti-psoriasis effect of water-processed rosin in mice. J Ethnopharmacol. 2019, 242, 112073.

 

2018

46.    Dai, P.; Ma, J.Y.; Huang, W.H.; Chen, W.X.; Wu, N.; Wu, S.F.; Li, Y.; Cheng, X.; Tan, R.X.* Photoredox C-F Quaternary Annulation Catalyzed by a Strongly Reducing Iridium Species. ACS Catal. 2018, 8, 802-806.

47.    Wu, L.; Tang, Y.P.; Shan, C.X.; Chai, C.; Zhou, Z.; Shi, X.Q.; Ding, N.; Wang, J.Y.; Lin, L.P.; Tan, R.X.* A comprehensive in vitro and in vivo metabolism study of hydroxysafflor yellow A. J Mass Spectrom. 2018, 53, 99-108.

48.    Wang, T.T.; Wei, Y.J.; Ge, H.M.; Jiao, R.H.; Tan, R.X.* Acaulide, an Osteogenic Macrodiolide from Acaulium sp H-JQSF, an Isopod-Associated Fungus. Org. Lett. 2018, 20, 1007-1010.

49.    Wang, T.T.; Wei, Y.J.; Ge, H.M.; Jiao, R.H.; Tan, R.X.* Acaulins A and B, Trimeric Macrodiolides from Acaulium sp H-JQSF. Org. Lett. 2018, 20, 2490-2493.

50.    Zhang, B.; Wang, K.B.; Wang, W.; Bi, S.F.; Mei, Y.N.; Deng, X.Z.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Discovery, Biosynthesis, and Heterologous Production of Streptoseomycin, an Anti-Microaerophilic Bacteria Macrodilactone. Org. Lett. 2018, 20, 2967-2971.

51.    Zhang, X.; Wang, T.T.; Xu, Q.L.; Xiong, Y.; Zhang, L.; Han, H.; Xu, K.; Guo, W.J.; Xu, Q.; Tan, R.X.*; Ge, H.M.* Genome Mining and Comparative Biosynthesis of Meroterpenoids from Two Phylogenetically Distinct Fungi. Angew. Chem. Int. Ed. 2018, 57, 8184-8188.

52.    Chen, Y.; Jiang, N.; Wei, Y.J.; Li, X.; Ge, H.M.; Jiao, R.H.; Tan, R.X.* Citrofulvicin, an Antiosteoporotic Polyketide from Penicillium velutinum. Org. Lett. 2018, 20, 3741-3744.

53.    Lin, L.P.; Tan, R.X.* Bioactive Alkaloids from Indole-3-carbinol Exposed Culture of Daldiniaeschscholzii. Chinese J. Chem. 2018, 36, 749-753.

54.    Wang, Y.S.; Zhang, B.; Zhu, J.P.; Yang, C.L.; Guo, Y.; Liu, C.L.; Liu, F.; Huang, H.Q.; Zhao, S.W.; Liang, Y.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. J. Am. Chem. Soc. 2018, 140, 10909-10914.

55.    Zhang, L.; Shi, J.; Liu, C.L.; Xiang, L.; Ma, S.Y.; Li, W.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* New borrelidin derivatives from an endophytic Streptomyces sp. Tetrahedron Lett. 2018, 59, 4517-4520.

 

2017

56.    Ma, S.Y.; Xiao, Y.S.; Zhang, B.; Shao, F.L.; Guo, Z.K.; Zhang, J.J.; Jiao, R.H.; Sun, Y.; Xu, Q.; Tan, R.X.*; Ge, H.M.* Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete. Org. Lett. 2017, 19, 6208-6211.

57.    Yang, C.L.; Wang, Y.S.; Liu, C.L.; Zeng, Y.J.; Cheng, P.; Jiao, R.H.; Bao, S.X.; Huang, H.Q.; Tan, R.X.*; Ge, H.M.* Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069. Mar. Drugs. 2017, 15, 244.

58.    Liu, X.D.; Tong, K.; Zhang, A.H.; Tan, R.X.*; Yu, S.Y. Metal-free chloroamidation of indoles with sulfonamides and NaClO. Org. Chem. Front. 2017, 4, 1354-1357.

59.    Li, G.W.; Cao, J.M.; Zong, W.; Hu, L.; Hu, M.L.; Lei, X.X.; Sun, H.; Tan, R.X.* Helical Polyisocyanopeptides as Lyotropic Liquid Crystals for Measuring Residual Dipolar Couplings. Chem. Eur. J. 2017, 23, 7653-7656.

60.    Xiao, Y.S.; Zhang, B.; Zhang, M.; Guo, Z.K.; Deng, X.Z.; Shi, J.; Li, W.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Rifamorpholines A-E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp Hca4. Org. Biomol. Chem. 2017, 15, 3909-3916.

61.    Zhang, A.H.; Liu, W.; Jiang, N.; Wang, X.L.; Wang, G.; Xu, Q.; Tan, R.X.*Sequestration of Guest Intermediates by Dalesconol Bioassembly Lines in Daldinia eschscholzii. Org. Lett. 2017, 19, 2142-2145.

62.    Wu, H.M.; Lin, L.P.; Xu, Q.L.; Han, W.B.; Zhang, S.; Liu, Z.W.; Mei, Y.N.; Yao, Z.J.; Tan, R.X.* Nodupetide, a potent insecticide and antimicrobial from Nodulisporium sp associated with Riptortus pedestris. Tetrahedron Lett. 2017, 58, 663-665.

 

2016

63.    Zhang, A.H.; Liu, W.; Jiang, N.; Xu, Q.; Tan, R.X.* Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor. Org. Lett. 2016, 18 (24), 6496–6499.

64.    Zhang, A. H.; Tan, R.; Jiang, N.; Kaidiriye, Y.; Wang, G.; Wang, X.L.; Tan, R.X. *Selesconol, a Fungal Polyketide That Induces Stem Cell Differentiation. Org. Lett. 2016, 18 (21), 5488–5491.

65.    Han, W. B.; Zhang, A. H.; Deng, X. Z.; Lei, X.; Tan, R.X. *Curindolizine, an Anti-inammatory Agent Assembled via Michael Addition of Pyrrole Alkaloids inside Fungal Cells. Org. Lett. 2016, 18, 18161819.

66.    Zong, W.; Li, G. W.; Cao, J. M.; Lei, X. X.*; Hu, M. L.; Sun, H.; Griesinger, C.; Tan, R.X.* An alignment medium for measuring residual dipolar couplings in pure DMSO: liquid crystals from graphene oxide grafted with polymer brushes. Angew. Chem. Int. Ed. 2016, 55,3690.

67.    Li, G. W.; Cao, J. M.; Zong, W.; Lei, X. X.*; Tan, R.X.* Enantiodiscrimination of carboxylic acids using the diphenylprolinol NMR chiral solvating agents. Org. Chem. Front. 2016, 3, 96–102.

 

2015

68.    Song, Y. N.; Zhang, W. J.; Bi, S. F.; Jiao, R. H.; Tan, R. X.*; Ge, H. M.* New ansamycin analogues from the mutant strain of Streptomyces seoulensis. J. Antibiot. 2015, 68, 757-759.

69.    Chen, C. J.; Zhou, Y. Q.; Liu, X. X.; Zhang, W. J.; Hu, S. S.; Lin, L. P.; Huo, G. M.; Jiao, R. H.; Tan, R. X.*; Ge, H. M.* Antimicrobial and anti-inflammatory compounds from a marine fungus Pleosporales sp. Tetrahedron Lett. 2015, 56, 6183–6189.

70.    Kong, L. Y.; Tan, R. X.* Artemisinin, a miracle of traditional Chinese medicine. Nat. Prod. Rep. 2015, 32, 1617–1621.

71.    Ren, R.; Chen, C. J.; Liu, X. X; Ge, H. M.; Tan, R. X.*; Jiao, R. H.* Bioactive trichothecenes produced by the Myrothecium sp. QB-1. Helv. Chim. Acta. 2015, 98, 1435–1441.

72.    Zhang, X.; Wei, W.; Tan, R. X.* Symbionts, a promising source of bioactive natural products. Sci. China Chem. 2015, 58, 1097–1109.

73.    Lin, L. P.; Yuan, P.; Jiang, N.; Mei, Y. N.; Zhang, W. J.; Wu, H. M.; Zhang, A. H,; Cao, J. M.; Xiong, Z. X.; Lu, Y.; Tan, R. X.* ene-inspired  mycosynthesis of skeletally new indole alkaloids. Org. Lett. 2015, 17, 2610–2613.

74.    Tian Y.; Zhao, G. Y.; Fang, W.; Xu, Q.; Tan, R. X.* 10(E)-sphingolipid desaturase involved in fusaruside mycosynthesis and stress adaptation in Fusarium graminearum. Sci. Rep. 2015, 5, 10486.

75.    Ren, R.; Chao, J. C.; Hu, S. S.; Hui, M. Ge.; Zhu, W. Y.; Tan, R. X.*, Jiao, R. H.* Drimane Sesquiterpenoids from the Aspergillus oryzae QXPC-4. Chem. Biodiv. 2015, 12, 371–379.

76.    Yao, L.Y.; Zhu, Y. X.; Liu, C. Q.; Jiao, R. H.; Lu, Y. H.*; Tan, R. X.* Preparative separation and purification of fumigaclavine C fromfermented mycelia of Aspergillus fumigatus CY018 by macroporousadsorption resin. J. Chromatogr. B 2015, 989, 122–128.

77.    Tian, Y.; Jiang, N.; Zhang, A. H.; Chen, C. J.; Deng, X. Z.; Zhang, W. J.; Tan, R. X.* Muta-mycosynthesis of naphthalene analogs. Org. Lett. 2015, 17, 1457–1460.

78.    Song, Y. N.; Jiao, R. H.; Zhang, W. J.; Zhao, G. Y.; Dou, H.; Jiang, R.; Zhang, A. H.; Hou, Y. Y.; Bi, S. F.; Ge, H. M.*; Tan, R. X.* New ansamycin derivatives generated by simultaneous mutasynthesis. Org. Lett. 2015, 17, 556–559.

79.    Han, W. B.; Dou, H.; Yuan, W. H.; Gong, W.; Hou, Y. Y.*; Ng, S. W.; Tan, R. X.* Meroterpenes with Toll-like receptor 3 regulating activity from the endophytic fungus Guignardia mangiferae. Planta Med. 2015, 81, 145–151.

80.    Chen, C. J.; Liu, X. X.; Zhang, W. J.; Zang, L. Y.; Wang, G.; Ng, S. W.; Tan, R. X.*; Ge, H. M.* Sesquiterpenoids isolated from an endophyte fungus Diaporthe sp. RSC Adv. 2015, 5, 17559–17565.

81.    Zhao, G. Y.; Fan, J. Y.; Hua, C. P.; Yan, W.; Chen, C. J.; Lu, Y. H.; Jiao, R. H.*; Tan, R. X.* Resveratrol improves fungal ribosylation capacity through a unique mechanism. RSC Adv. 2015, 5, 5657–5663.

 

2014

82.    Yan, W.; Ge, H. M.; Wang, G.; Jiang, N.; Mei,Y. N.; Jiang, R.; Li, S. J.;  Chen, C. J.; Jiao, R. H.; Xu, Q.; Ng, S. W.; Tan, R. X.* Pictet–Spengler  reaction based biosynthetic machinery in fungi. Proc. Natl.Acad. Sci. USA 2014, 111, 18138–18143.

83.    Guo, Z. K.; Wang, R.; Huang, W.; Li, X. N.; Jiang, R. Tan, R. X.*; Ge, H.  M.* Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp. YXf3. Beilstein J. Org. Chem. 2014, 10, 2677–2682.

84.    Wang, X.; Zhang, A.; Gao, J.; Chen,W.; Wang, S.; Wu, X.; Shen, Y.; Ke, Y.;  Hua, Z.; Tan, R. X.*; Sun, Y.*; Xu, X.* Trichomide A, a natural  cyclodepsipeptide, exerts immunosuppressive activity against activated  T-lymphocytes by upregulating shp2 activation to overcome contact  dermatitis. J. Invest. Dermatol. 2014, 134, 2737–2746.

85.    Shen, L. Luo, Q.; Shen, Z. P.; Li, L. Y.; Zhang, X. J.; Wei, Z. Q.; Fu, Y.; Song, Y. C.; Tan, R. X.*. A new cytochalasin from endophytic Phomopsis sp. IFB-E060. Chin. J. Nat. Med. 2014, 12, 512–516.

86.    Gong, W.; Lu, E. L.; Dou, H.; Song, Y. X.;Yang, L.;Ji, J. J.; Li, E. G.; Tan, R. X.* Hou, Y. Y.* A novel 1,2-benzenediamine derivative FC-99  suppresses TLR3 expression and ameliorates disease symptoms in a mouse  model of sepsis. Br. J. Pharmacol. 2014, 171, 1577–1579.

87.    Han, W. B.; Lu, Y. H.; Zhang, A. H.; Zhang, G. F.; Mei, Y. N.; Jiang, N.; Lei, X. X. Song, Y. C.; Tan, R. X.* Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species. Org. Lett. 2014, 16, 5366–5369.

88.    Chen, C. J.; Jiang, R.; Wang, G.; Jiao, R. H.; Tancharoen, C.; Sudto,K.;  Vajarothi, S.; Hannongbua, S.; Ge, H. M.*; Tan, R. X.* Oligostibenoids  with acetylcholinesterase inhibitory activity from Dipterocarpus alatus. Planta Med. 2014, 80, 1641–1646.

89.    Zhang, W.; Qiao, H. S.; Lv, Y. Z.; Wang, J. J.; Chen, X. Q.; Hou, Y. Y.; Tan, R. X.*; Li, E. G.* pigenin Inhibits Enterovirus-71 Infection by disrupting viral RNA association with trans-acting factors. PLoS ONE 2014, 9, e110429.

90.    Huang, W.; Zhang, W. J.; Cheng, Y. Q.; Jiang, R.; Wei, W.; Chen, C. J.; Wang, G.; Jiao, R. H.; Tan, R. X. *; Ge, H. M. * Cytotoxic and antimicrobial flavonoids from Cryptocarya concinna. Planta Med. 2014, 80, 925–930.

91.    Wei, W.; Gao, J.; Shen, Y.; Chu, Y. L.; Xu, Q.*; Tan, R. X. * Immunosuppressive diterpenes from Phomopsis sp. S12. Eur. J. Org. Chem. 2014, 5728–5734.

92.    Xu, J.; Song, Y. C.*; Guo, Y.; Mei, Y. N.; Tan, R. X. * Fumigaclavines D–H, new ergot alkaloids from endophytic Aspergillus fumigatus. Planta Med. 2014, 80, 1131–1137.

93.    Wu, Q.; Jiang,N.; Han, W. B.; Mei,Y. N.; Ge, H. M.; Guo, Z. K.; Weng, N.  S.; Tan, R. X.* Antibacterial epipolythiodioxopiperazine and unprecedented sesquiterpene from Pseudallescheria boydii, a beetle (coleoptera)-associated fungus Org. Biomol. Chem. 2014, 12, 9405–9412.

94.    Lei, X. X. *; Xu, Z.; Sun, H.; Wang, S.; Christian Griesinger, Peng, L.; Gao, C.*; Tan, R. X.* Graphene oxide liquid crystals as a versatile and tunable alignment medium for the measurement of residual dipolar couplings in organic solvents. J. Am. Chem. Soc. 2014, 136, 11280–11283.

95.    Wu, H. C.; Ge, H. M.; Zang, L. Y.; Bei, Y. C.; Niu, Z. Y.; Wei, W.; Feng, X. J.; Ding, S.; N, S. W.; Shen, P. P. *; Tan, R. X.* Diaporine, a novel endophyte-derived regulator of macrophage differentiation. Org. Biomol. Chem. 2014, 12, 6545–6548

96.    Zhu, Y. X.; Yao, L. Y.; Jiao, R. H.; Lu, Y. H. *; Tan, R. X.* Enhanced production of fumigaclavine C in liquid culture of Aspergillus fumigatus under a two-stage process. Bioresource Technol. 2014, 152, 162–168

97.    Yao, L. Y.; Zhu, Y, X.; Jiao, R. H.; Lu, Y. H. *.; Tan, R. X.* Enhanced production of fumigaclavine C by ultrasound stimulation in a two-stage culture of Aspergillus fumigatus CY018. Bioresource Technol. 2014, 159, 112–117.

98.    Wei, W.; Jiang, N.; Mei, Y. N.; Chu, Y. L.; Ge, H. M.; Song, Y. C.; N, S. W.; Tan, R. X.* An antibacterial metabolite from Lasiodiplodia pseudotheobromae F2. Phytochemistry. 2014, 100, 103-109.

 

2013

99.    Qiao, H. S.; Chen, X. Q.; Xu, L. F.; Wang, J. J.; Zhao, G. Y.; Hou, Y. Y.; Ge, H. M.; Tan, R. X.*; Li, E. G.* Antitumor effects of naturally occurring oligomeric resveratrol derivatives. FASEB J. 2013, 27, 4561–4571.

100.Zhang, A. H.; Wang, X. Q.; Han, W. B.; Sun, Y.; Guo, Y.; Wu, Q.; Ge, H. M.; Song, Y. C.; Ng, S. W.; Xu, Q. *; Tan, R. X.* Discovery of a New Class of Immunosuppressants from Trichothecium roseum Co-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif. Chem. Asian J. 2013, 8, 3101–3107.

101.Wurin, G. G.; Guo, Z. K.; Wei, W.; Jiao, R. H.; Yan, T.; Zang, L. Y.; Jiang, R.; Tan, R. X.*, Ge, H. M.* Polyketides from the plant endophytic fungus Cladosporium sp. IFB3lp-2. J. Asian. Nat. Prod. Res. 2013, 15, 928–933.

102.Song, Y.  X.; Dou, H.; Gong, W.; Liu, X. Q.; Yu, Z. G.; Li, E. G.; Tan, R. X.*; Hou, Y. Y.* Bis-N-norgliovictin, a small-molecule compound from marine fungus, inhibits LPS-induced inflammation in macrophages and improves survival in sepsis Eur. J. Pharmacol. 2013, 705, 49–60.

103.Bi, S. F.; Guo, Z. K.; Jiang, N.; Jiao, R. H.; Ge, H. M.; Tan, R. X.* New alkaloid from Streptomyces koyangensis residing in Odontotermes formosanus. J. Asian. Nat. Prod. Res. 2013, 15, 422–425.

104.Jiao, R. H.; Xu, H.; Cui, J. T.; Ge, H. M.; Tan, R. X.* Neuraminidase Inhibitors from marine-derived actinomycete Streptomyces seoulensis. J. Appl. Microbiol. 2013, 114, 1046–1053.

105.Feng, L. L.; Wu, X. F.; Liu, H. L.; Guo, W. J.; Luo, Q.; Tao, F. F.; Ge, H.  M.; Shen, Y.; Tan, R. X.*; Xu, Q.*; Sun,Y.* Vaticaffinol, a resveratrol  tetramer, exerts more preferable immunosuppressive activity than its  precursor in vitro and in vivo through multiple aspects against  activated T lymphocytes. Toxicol. Appl. Pharm. 2013, 267, 167–173.

106.Guo, Z. K.; Jiao, R. H.; Dai, H. F.; Mei, W. L.; Tan, R. X.; Ge, H. M.  Actinotetraoses I-K, tetrasaccharide metabolites produced by an insect-der actinobacterium Amycolatopsis sp. HCa1. Chem. Biodivers. 2013, 10, 296–302.

107.Wu, Q.; Guo, Y.; Guo, Z. K.; Chu, Y. L.; Wang, T.; Tan, R. X.* Two new cytosporones from the culture of endophytic Phomopsis sp. Chem. Nat. Compd. 2013, 48, 938-941.

108.Zhu, X. L.; Ye, L.; Ge, H. M.; Chen, L.; Jiang, N.; Qian, L.; Li, L. L.; Liu, R.; Ji, S.; Zhang, S.; Jin, J. L.; Guan, D. N.; Fang, W.; Tan, R. X.*; Xu, Y.* Hopeahainol A attenuates memory deficits by targeting -amyloid in APP/PS1 transgenic mice. Aging Cell 2013, 12, 85–92.

109.Hua, C. Y.; Yang, Y. H.; Sun, L.; Dou, H.; Tan, R. X. *; Hou, Y. Y.* Chaetoglobosin F, a small molecule compound, possesses immunomodulatory properties on bone marrow-derived dendritic cells via TLR9 signaling pathway. Immunobiology, 2013, 218, 292–302.

 

2012

110.Lin, L.; Ge, H. M.; Yan, T.; Qin, Y. H.; Tan, R. X. * Thaxtomin A-deficient endophytic Streptomyces sp. enhances plant disease resistance to pathogenic Streptomyces scabies. Planta, 2012, 236, 1849–1861.

111.Wu, X. X.; Guo, W. J.; Wu, L. M.; Gu, Y. H.; Gu, L. Y.; Xu, S. H.; Wu, X.  F.; Shen, Y.; Ke, Y. H.; Tan, R. X.; * Sun,Y.; Xu,Q. * Selective  sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2  ameliorates murine experimental colitis. J. Immunol. 2012, 189, 3497–3507.

112.Guo, Z. K.; Liu, S. B.; Jiao, R. H.; Wang, T.; Tan, R. X.; * Ge, H. M. * Angucyclines from an insect-derived actinobacterium Amycolatopsis sp.  HCa1 and their cytotoxic activity. Bioorg. Med. Chem. Lett. 2012, 22, 7490–7493.

113.Fang, W.; Ji, S.; Jiang, N.; Wang, W.; Zhao, G. Y.; Zhang, S.; Ge, H. M.; Xu, Q.; Zhang, A. H.; Zhang, Y. L.; Song, Y. C.; Zhang, J.; Tan, R. X.* Naphthol radical couplings determine structural features and enantiomeric excess of dalesconols in Daldinia eschscholzii. Nat. Commun. 2012, 3: 1039.

114.Chen, X. Q.; Qiao, H. S.; Liu, T. X.; Yang, Z. Y.; Xu, L. F.; Xu, Y. X.; Ge, H. M.; Tan, R. X.*; Li, E. G.* nhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation. Antivir. Res. 2012, 95, 30–36.

115.Zang, L. Y.; Wei, W.; Wang, T.; Guo, Y.; Tan, R. X.*; Ge, H. M. sochromophilones from an endophytic fungus Diaporthe sp. Nat. Prod. Bioprospect. 2012, 2, 117–120.

116.Sun, L.; Hua, C. Y.; Yang, Y. H.; Dou, H.; Li, E. G.; Tan, R. X.*; Hou*,Y.  Y. Chaeoglobosin Fex inhibits poly(I:C)-induced activation of bone marrow-derived dendritic cells. Mol. Immunol. 2012, 51, 150–158.

117.Ge, H. M.; Sun, H.; Jiang, N.; Qin, Y. H.; Dou, H.; Yan, T.; Hou, Y. Y.; Griesinger, C.*; Tan, R. X.* Relative and absolute configuration of vatiparol (1 mg): a novel antiinflammatory polyphenol. Chem. Eur. J. 2012, 18, 5213–5221.

118.Jiao, R. H.; Cui, J. T.; Wang, T.; Zhang. A. H.; Tan, R. X. * Trichothecin induces apoptosis of HepG2 cells via caspase-9 mediated activation of the mitochondrial death pathway. Toxicon 2012, 59, 143–150.

 

2011

119.Zhou, T.; Song, Y. C. *; Feng, M. Q.; Tan, R. X.* Cloning, expression and biochemical characterization of UDP-glucose 6-dehydrogenase, a key enzyme in the biosynthesis of an anti-tumor polysaccharide from the marine fungus Phoma herbarum YS4108. Process Biochem. 2011, 46, 2263–2268.

120.Wu Q.; Song*, Y. C.; Xu H.; Guo Y.; Li J.; Tan, R. X.* Medium optimization for enhanced co-production of two bioactive metabolites in the same fermentation by a statistical approach. J. Asian Nat. Prod. Res. 2011, 13, 1110–1121.

121.Dou H.; Song Y. X.; Liu X. Q.; Gong W.; Li E. G.; Tan, R. X.*; Hou Y. Y.  Chaetoglobosin Fex from the marine-derived endophytic fungus inhibits induction of inflammatory mediators via Toll-Like receptor 4 signaling in macrophages. Biol. Pharm. Bull. 2011, 34, 1864–1873.

122.Xu H.; Jiang N.; Guo Y.; Jiao R. H.; Cui J. T.; Song Y. C.; Tan, R. X.*.  Fully substituted unsaturated lactones from endophytic Myrothecium sp. J. Asian Nat. Prod. Res. 2011, 13, 1003–1007.

123.Du, R. H.; Li, E. G.; Cao, Y.; Song, Y. C.; Tan, R. X.* Fumigaclavine C inhibits tumor necrosis factor production via suppression of toll-like receptor 4 and nuclear factor B activation in macrophages. Life Sci. 2011, 89, 235–240.

124.Zhang Y. L.; Zhang J.; Jiang N.; Lu Y. H.; Wang L.; Xu S. H.; Wang W.; Zhang G. F.; Xu Q.; Ge H. M.; Ma J.; Song Y. C.; Tan, R. X.*.  Immunosuppressive polyketides from mantis-associated Daldinia  eschscholzii. J. Am. Chem. Soc. 2011, 133, 5931–5940.

125.Lin L.; Tan, R. X.* Cross-kingdom actions of phytohormones: a functional scaffold exploration. Chem. Rev. 2011, 111, 2734–2760.

126.Ge H. M.; Yan W.; Guo Z. K.; Luo Q.; Feng R.; Zang L. Y.; Shen Y.; Jiao R.  H.; Xu Q.; Tan, R. X.* Precursor-directed Q1 fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action.Chem. Commun. 2011, 47, 2321–2323.

127.Ge H. M.; Zhang Q.; Xu S. H.; Guo Z. K.; Song, Y. C.; Huang, W. Y.; Tan, R. X.* Chaetoglocins A–D, four new metabolites from the endophytic fungus Chaetomium globosum. Planta Med. 2011, 77, 277–280.

 

2010

128.Zhang, A.H.; Jiang, N.; Gu, W.; Ma, J.; Wang, Y.R.; Song, Y.C.; Tan, R.X.*. Characterization, synthesis and self-aggregation of (-)-alternarlactam, a novel fungal cytotoxin with cyclopentenone and isoquinolinone Scaffolds. Chem. Eur. J. 2010, 16,14479–14485.

129.uan, W. H.; Liu, M.; Jiang, N.; Guo, Z. K.; Ma, J.; Zhang, J.; Song, Y. C.; Tan, R.X.* Guignardones A–C: three meroterpenes from Guignardia   mangiferae. Eur. J. Org. Chem. 2010, 6348–6353.

130.Zhang, J.; Ge, H. M.; Jiao, R. H.; Li, J.; Peng, H.; Wang, Y. R.; Wu, J. H.; Song, Y. C.; Tan, R.X.* Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. Planta Med. 2010, 76, 1910–1914.

131.Zhang, H. W; Zhang, J.; Hu, S.; Zhang, Z. J.; Zhu, C. J.; Ng, S. W.; Tan, R. X.*. Ardeemins and cytochalasins from Aspergillus terreus residing in Artemisia annua. Planta Med. 2010, 76, 1616–1621.

132.Wu, J. H.; Wang, Y. R.; Huang, W. Y.; Tan, R.X.* Anti-proliferative and pro-apoptotic effects of tectorigenin on hepatic stellate cells. World J. Gastroentero. 2010, 16, 3911–3918.

133.Shen, J. S.; Wang, H. J.; Shen, Y. C.; Tan, R.X.* A new cytotoxic trichothecene macrolide from the endophyte Myrothecium roridum. Planta Med. 2010, 76, 1004–1006.

134.Ge, H. M.; Yang, W. H.; Shen, Y.; Jiang, N.; Guo, Z. K.; Xu Q.; Ma, J.; Tan, R.X.* Novel and immunosuppressive resveratrol aneuploids from Hopea chinensis. Chem. Eur. J. 2010, 16, 6338–6345.

135.Wang, Q. Z.; Ge, H. M.; Zhang, J.; Wu, J. H.; Song, Y. C.;Zhang, Y. F.; Tan, R. X.*. Cochliones A-D, four new tetrahydrochromanone derivatives from endophytic Cochliobolus sp.  J. Asian Nat. Prod. Res. 2010, 12, 485–491.

136.Ge, H. M.; Peng, H.; Guo, Z. K.; Cui, J. T.; Song, Y. C., Tan, R.X.*. Bioactive alkaloids from the plant endophytic fungus Aspergillus terreus. Planta Med. 2010, 76, 822–824.

 

2009

137.Ge, H. M.; Yang, W.; Zhang, J.; Tan, R.X.* Antioxidant oligostilbenoids from the stem wood of Hopea hainanensis. J. Agric. Food Chem. 2009, 57, 5756–5761.

138.Xu, S.; Ge, H. M., Song, Y. C., Shen, Y.; Ding H.; Tan, R.X.* Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa. Chem. Biodivers. 2009, 6, 739–745.

139.Sang, Y. S.; Zhou, C. Y.; Lu, A. J.; Yin, X. J.; Min, Z. D.; Tan, R.X.*. Protolimonoids from Melia toosendan. J. Nat. Prod. 2009, 72, 917–920.

140.Shi, D. H.;Wu, J. H.; Ge, H. M., Tan, R.X.* Protective effect of   hopeahainol A, a novel acetylcholinesterase inhibitor on hydrogen peroxide-induced injury in PC12 cells. Environ. Toxicol. Pharm. 2009, 28, 30–36.

141.Ge, H. M.; Yu, Z. G.; Zhang, J.; Wu, J. H.; Tan, R.X.* Bioactive alkaloids from endophytic Aspergillus fumigatus. J. Nat. Prod. 2009, 72, 753–755.

142.Ge, H. M.; Jiao, R. H.; Zhang, Y. F.; Zhang, J. Wang, Y. R.; Tan, R.X.*   Cytotoxicity and phytotoxicity of trichothecene macrolides from Myrothecium gramminum. Planta Med. 2009, 75, 227–220.

143.Ge, H. M.; Tan, R.X.* Symbionts, an important source of new bioactive natural products. Progress in Chemistry 2009, 21, 30-46.

144.Hu, S. C.; Hong, K.*; Song, Y. C.; Liu, J. Y.; Tan, R.X.* Streptomyces sp. 060524 and cytotoxicity of the products. World J. Microb. Biot. 2009, 25, 115–121.

 

2008

145.Zhang, Y. L.; Ge, H. M.; Song, F. Li.; Song, Y. C., Tan, R. X.* New phytotoxic metabolites from Pestalotiopsis sp. HC02, a Fungus Residing in Chondracris rosee gut.  Chem. Biodivers. 2008, 5, 2402–2407.

146.Feng, M. Q.; Zhou, T.; Wei, W. J.; Song, Y. C.; Tan, R. X.* Tn5 transposase-assisted high-efficiency transformation of filamentous fungus Phoma herbarum YS4108. Appl. Microbiol. Biot. 2008, 80, 937–944.

147.Zhang, H. W.; Huang, W. Y.; Chen, J. R.; Yan, W. Z.; Xie, D. Q.; Tan, R. X.*.  Cephalosol, an Antimicrobial Metabolite with an Unprecedented Skeleton from Endophytic Cephalosporium acremonium IFB-E007. Chem. Eur. J. 2008, 14, 10670–10674.

148.Ge, H. M.; Zhang, W. Y.; Ding, G.; Saparpakorn, P.; Song, Y. C.; Hannongbua, S. Tan, R. X.* Chaetoglobins A and B, two unusual alkaloids  from endophytic Chaetomium globosum culture. Chem. Commun. 2008, 45, 5978–5980.

149.Shi, D. H.; Xu, C.; Guo, B. X.; Wang, X. T.; Chen, Y. X.; Tan, R. X.* Inhibition of soluble epoxide hydrolase by extracts derived from inflammation-treating Chinese medicinal herbs. Phytother. Res. 2008, 22, 1264–1268.

150.Zhang, Y. L.; Ge, H. M.; Zhao, W., Dong, H.; Xu, Q.; Li, S. H.; Zhang, J.; Song, Y. C., Tan, R. X.* Unprecedented immunosuppressive polyketides from Daldinia eschscholzii, a mantis-associated fungus. Angew. Chem. Int. Ed. 2008, 47, 5823–5826.

151.Gao, X. X.; Ge, H. M.; Zhang, W. F.; Tan, R. X.* NMR-based metabonomics for detection of Helicobacter pylori infection in gerbils: Which is more descriptive. Helicobacter 2008, 13, 103–111.

152.Ge, H. M., Shen, Y., Zhu, C. H., Tang, S. H.; Ding, H.; Song, Y. C.; Tan, R. X.* Penicidones A-C, three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp. Phytochemistry 2008, 69, 571–576.

153.Ge, H. M.; Zhu, C. H.; Shi, D. H.; Yang, J.; Ng, S. W.; Tan, R. X.* Hopeahainol A, an acetylcholinesterase inhibitor from Hopea hainanensis. Chem. Eur. J. 2008, 14, 376–381.

 

专著:


1. 谭仁祥主编,王剑文副主编. 《甾体化学》,化学工业出版社,北京,2008(43.6万字)。

2. 谭仁祥主编,石建功、郭跃伟、徐琛副主编. 《功能海洋生物分子——发现与应用》,科学出版社,北京,2007(110.9万字)。

3. 谭仁祥主编,王剑文、徐琛、崔贵友副主编. 《植物成分功能》,科学出版社,北京,2003(110.3万字)。

4. 谭仁祥主编,孟军才、陈道峰、焦庆才副主编.《植物成分分析》,科学出版社,北京,2002(100.6万字,2004年再版)。


代表性专利:


1. 谭仁祥、卫蔚、姜荣、赵国琰. 一种二萜Libertellenone G及其制备方法与用途。申请号: 201310039647.0;申请日2013.1.31.。

2. 谭仁祥、张高飞、宋勇春、崔江涛、汪伟. 一种弯孢霉菌及吲哚里西啶生物碱的制备方法和应用。发明专利号:ZL 2011 1 0105504.6;证书号:第1175021号

3. 谭仁祥、毕淑峰、梅亚宁、宋勇春、郭也、李方. 新大环内酯及其制备方法和应用。发明专利号:ZL 2011 1 0027900.1;证书号:第1010622号。

4. 谭仁祥、汪伟、宋雅男、沈薇、宋勇春. 一种单一型黑色素及其制备方法和应用。发明专利号:ZL 2011 1 0099493.5;证书号:第1014928号。

5. 谭仁祥、张爱华、谷文、宋勇春、王玉蓉、胥苏海. 一类交链孢菌生物碱及其制备方法和用途。发明专利号:ZL 2010 1 0180422.3。证书号:第1175280号。

6. 谭仁祥、史大华、吴俊华、宴志强、张丽娜、王玉蓉. 4′,5-二羟基-7-[4-(N,N-二乙氨基)丁氧基]异黄酮及其制备方法和应用。发明专利号:ZL 2010 1 0573851.7 ;证书号:第1025266号。

7. 谭仁祥、宋勇春、乔红运、梅亚宁、刘敏、吴琦. 汉城链霉素及其制备方法和应用。发明专利号:ZL 2010 1 0180437.X;第978509号。

8. 谭仁祥、章华伟、黄午阳、陈菁蓉、谢代前. 一种顶头孢菌素及其制法和用途。发明专利号:ZL 2008 1 0020996.7。证书号:第753083号。

9. 谭仁祥、徐强、张应烙、赵蔚、黎书华. 一类炭壳菌聚酮及其制法与用途。发明专利号:ZL 2007 1 0191967.2;证书号:第816924号。

10. 谭仁祥、吴俊华、徐琛、陈运喜、李洪森、李方、周添. 一种鸢尾的医药用途。发明专利号:ZL 2006 1 0040333.2。证书号:第535870号。