焦瑞华
教授、博士生导师
办公地点：生科楼A408
Email：rhjiao@nju.edu.cn
学习和进修经历:
2011.03 香港理工大学 专题研习班
2001.9.01-2006.6.20 南京大学 理学博士（硕博连读）
工作经历:
2011年 南京大学“青年骨干教师”
2019.12至今 南京大学生命科学学院 教授
2009.12-2019.12 南京大学生命科学学院 副教授
2006.8-2009.12 南京大学生命科学学院 讲师
获奖情况:
2007年 植物内生真菌代谢物研究教育部2007年度高等学校科学技术奖自然科学奖一等奖，第四完成人
2007年 江苏省优秀博士论文
2006年 美国“百人会”英才奖
学术兼职:
1、2011年至今中国微生物学会海洋微生物学专业委员会 委员
学术论文:
2023
1. Yi Ling Hu#, Qi Zhang#, Shuang He Liu, Jia Li Sun, Fang Zhou Yin, Zi Ru Wang, Jing Shi, Rui Hua Jiao*, Hui Ming Ge*. Building Streptomycesalbus as a chassis for synthesis of bacterial terpenoids. Chem. Sci.2023, 14(13), 3661–3667.
2. Lang Xiang, Jing Shi*, Ao Zhu, Zi Fei Xu, Shuang He Liu, Yi Shuang Wang, Zhi Kai Guo, Rui Hua Jiao, Ren Xiang Tan*, Hui Ming Ge*. Total Biosynthesis of Mutaxanthene Unveils a Flavoprotein Monooxygenase Catalyzing Xanthene Ring Formation. Angew. Chem. Int. Ed.2023, 62(13), e202218660.
3. Yu Meng Yang#, Er Juan Zhao#, Wanqing Wei#, Zi Fei Xu, Jing Shi, Xuan Wu, Bo Zhang, Yasuhiro Igarashi, Rui Hua Jiao*, Yong Liang*, Ren Xiang Tan, and Hui Ming Ge*. Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis of Trialkyl-Substituted Aromatic Polyketides.Angew. Chem. Int. Ed.2023, 62(5), e202214026.
2022
4. Jing Shi, Yang Shi, Jian Cheng Li, Wanqing Wei, Yu Chen, Ping Cheng, Cheng Li Liu, Hao Zhang, Rui Wu, Bo Zhang, Rui Hua Jiao, Shouyun Yu, Yong Liang*, Ren Xiang Tan*, Hui Ming Ge*. In Vitro Reconstitution of Cinnamoyl Moiety Reveals Two Distinct Cyclases for Benzene Ring Formation. J. Am. Chem. Soc.2022, 144(17), 7939–7948.
5. Shuang He Liu, Jia Li Sun, Yi Ling Hu, Li Zhang, Xuan Zhang, Zhang Yuan Yan, Xing Guo, Zhi Kai Guo, Rui Hua Jiao, Bo Zhang*, Ren Xiang Tan*, Hui Ming Ge*. Biosynthesis of Sordarin Revealing a Diels-Alderase for the Formation of the Norbornene Skeleton. Angew. Chem. Int. Ed.2022, 61(33), e202205577.
6. Zhi-Kai Guo, Wen-Yong Zhu, Li-Xing Zhao, Yan-Chi Chen, Sui-Jun Li, Ping Cheng, Hui-Ming Ge, Ren-Xiang Tan, Rui-Hua Jiao*. New antibacterial depsidones from an ant-derived fungus Spiromastix sp. MY-1. Chin. J. Nat. Med.2022, 20(8), 627–632.
7. Yu Li#, Zifei Xu#, Liyifan Chen#, Mengyue Zhu, Dacheng Wang ,Maofeng Jing, Yiliang Chen, Ziqian Sun, Yiming Wang, Bo He, Wei Yan, Ruihua Jiao*, Yonghao Ye*. New metabolites from Streptomyces pseudovenezuelae NA07424 and their potential activity of inducing resistance in plants against Phytophthora capsici. Pest Manag. Sci.2022, 79(1), 349–356.
8. Hong Jie Zhu#, Bo Zhang#, Wanqing Wei#, Shuang He Liu, Lang Xiang, Jiapeng Zhu, Rui Hua Jiao, Yasuhiro Igarashi, Ghader Bashiri, Yong Liang, Ren Xiang Tan*, Hui Ming Ge*. AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis.Nat. Commun.2022, 13(1), 4499.
9. , , , , , *,*.. Nat. Prod. 2022, 85, 1442–1447.
10. Xuan Zhang#, Xian-Xian Liu#, Yin-Nan Xing, Mei Zhang, Yang Zhao, Yuan-Yuan Wei, Bo Zhang*, Rui-Hua Jiao*. Alternatones A and B, two polyketides possessing novel skeletons from entophyte Alternaria alternate L-10.J. Asian Nat. Prod. Res.2022, 24(4), 353–360.
11. Jing Shi, Jia-Qi Ma, Yong-Chao Wang, Zi-Fei Xu, Bo Zhang, Rui-Hua Jiao, Ren-Xiang Tan, Hui-Ming Ge*. Discovery of daspyromycins A and B, 2-aminovinyl-cysteine containing lanthipeptides, through a genomics-based approach.Chin. Chem. Lett.2022, 33(1), 511–515.
2021
12. Fang Wen Jiao#, Yi Shuang Wang#, Xue Ting You, Wanqing Wei, Yu Chen, Cheng Long Yang, Zhi Kai Guo, Bo Zhang, Yong Liang*, Ren Xiang Tan*, Rui Hua Jiao*, Hui Ming Ge*.An NADPH-Dependent Ketoreductase Catalyses the Tetracyclic to Pentacyclic Skeletal Rearrangement in Chartreusin Biosynthesis.Angew. Chem. Int. Ed.2021, 60(50),26378–26384.
13. Jing Shi#, Xiang Xu#, Pei Yi Liu, Yi Ling Hu, Bo Zhang, Rui Hua Jiao, Ghader Bashiri, Ren Xiang Tan*, Hui Ming Ge*. Discovery and biosynthesis of guanipiperazine from a NRPS-like pathway. Chem. Sci.2021, 12(8):2925–2930.
14. Zhi Wu Tong, Xia Hong Xie, Ting Ting Wang, Ming Lu, Rui Hua Jiao, Hui Ming Ge, Gang Hu, Ren Xiang Tan*. Acautalides A–C, Neuroprotective Diels-Alder Adducts from Solid-State Cultivated Acaulium sp. H-JQSF. Org. Lett. 2021, 23(14), 5587–5591.
15. Shuang He Liu#, Yuan Yuan Wei#, Yin Nan Xing, Yu Chen, Wen Wang, Kai Biao Wang, Yong Liang, Rui Hua Jiao*, BoZhang*, and Hui Ming Ge*. A BBE-like Oxidase, AsmF, Dictates the Formation of Naphthalenic Hydroxyl Groupsin Ansaseomycin Biosynthesis. Org. Lett. 2021, 23(9), 3724–3728.
16. Zhikai Guo#*, Shiying Ma#, Salman Khan, Hongjie Zhu, Bo Zhang, Shiqing Zhang and Ruihua Jiao*. Zhaoshumycins A and B, Two Unprecedented Antimycin-Type Depsipeptides Produced by the Marine-Derived Streptomyces sp. ITBB-ZKa6. Marine Drugs, 2021, 19(11), 624.
2020
17. Wei Li, Jing Wei, Dao-Ying Chen, Mei-Jing Wang, Yang Sun, Fang-Wen Jiao, Rui-Hua Jiao, Ren-Xiang Tan*, Hui-Ming Ge*. Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410. Chin. J. Nat. Med.2020, 18(12), 957–960.
18. Sui Jun Li, Fang Wen Jiao, Wei Li, Xuan Zhang, Wei Yan*, Rui Hua Jiao*. Cytotoxic Xanthone Derivatives from the Mangrove-Derived Endophytic Fungus Peniophora incarnata Z4.J. Nat. Prod.2020, 83(10), 2976–2982.
19. Wei Li, Fang-Wen Jiao, Jia-Qi Wang, Jing Shi, Ting-Ting Wang, Salman Khan, Jiao Rui-Hua, Ren-Xiang Tan*, Hui-Ming Ge*. Unguisin G, a new kynurenine-containing cyclic heptapeptide from the sponge-associated fungus Aspergillus candidus NF2412.Tetrahedron Lett.2020, 61(40), 152322.
20. Zi Fei Xu#, Sheng Tao Bo#, Mei Jing Wang, Jing Shi, Rui Hua Jiao, Yang Sun, Qiang Xu, Ren Xiang Tan*, Hui Ming Ge*. Discovery and biosynthesis of bosamycins from Streptomyces sp. 120454. Chem Sci.2020, 11(34):9237–9245.
21. Cheng Long Yang, Bo Zhang, Wen Wen Xue, Wu Li, Zi Fei Xu, Jing Shi, Yan Shen, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge*. Discovery, Biosynthesis, and Heterologous Production of Loonamycin, a Potent Anticancer Indolocarbazole Alkaloid.Org. Lett. 2020, 22(12), 4665–4669.
22. He-Zhong Jiang, Sha Hu, Ren-Xiang Tan, Rui Tan, Rui-Hua Jiao*. Jiang HZ, Hu S, Tan RX, Tan R, Jiao RH. Neocucurbitacin D, a novel lactone-type norcucurbitacin as xanthine oxidase inhibitor from Herpetospermum pedunculosum. Nat. Prod. Res.2020, 34(12), 1728–1734.
23. Yingzi Tan, Zhikai Guo, Mengyue Zhu, Jing Shi, Wei Li, Ruihua Jiao, Renxiang Tan, Huiming Ge*. Anti-inflammatory spirobisnaphthalene natural products from a plant-derived endophytic fungus Edenia gomezpompae. Chin. Chem. Lett. 2020, 31(6), 1406–1409.
24. Jiayu Zhao#, Anqi Xiao#, Chunyu Liu#, Chao Ye, Kai Yin, Minghon Lu, Ruihua Jiao*, Xi Chen*, Chenyu Zhang*, Minghui Liu*. TheHIF-1A/miR-17-5p/PDCD4 axis contributes to the tumor growth and metastasis of gastric cancer. Signal Transduct. Target. Ther.2020, 5(1), 46.
25. Zhikai Guo*, Yiqing Cheng, Wei Huang, Ruihua Jiao*. Shoreanol A and B, unprecedented oligostilbenoids from the twigs of Shorea obtusa Wall. Fitoterapia,2020, 142, 104502.
26. Minmin Fan#, Gang Xiang#, Jingwei Chen, Jian Gao, Wenwen Xue, Yixuan Wang, Wuhao Li, Lin Zhou, Ruihua Jiao, Yan Shen*, Qiang Xu*. Libertellenone M, a diterpene derived from an endophytic fungus Phomopsis sp. S12, protects against DSS-induced colitis via inhibiting both nuclear translocation of NF-κB and NLRP3 inflammasome activation. Int. Immunopharmacol.2020, 80, 106144.
27. Guang Zhi Dai, Wen Bo Han, Ya Ning Mei, Kuang Xu, Rui Hua Jiao, Hui Ming Ge, Ren Xiang Tan*. Pyridoxal-5'-phosphate-dependent bifunctional enzyme catalyzed biosynthesis of indolizidine alkaloids in fungi. Proc. Natl. Acad. Sci. U. S. A.2020, 117(2), 1174–1180.
2019
28. Kuang Xu#, Xuan Zhang#, Jing Wei Chen, Yan Shen, Nan Jiang, Ren Xiang Tan, Rui Hua Jiao*, Hui Ming Ge*. Anti-inflammatory diterpenoids from an endophytic fungus Phomopsis sp. S12.Tetrahedron Lett.2019, 60(38), 151045.
29. Shi, Jing#; Xu, Xiang#; Zhao, Er Juan; Zhang, Bo; Li, Wei; Zhao, Yang; Jiao, Rui Hua*; Tan, Ren Xiang; Ge, Hui Ming*. Genome Mining and Enzymatic Total Biosynthesis of Purincyclamide. Org. Lett. 2019, 21(17),6825-6829.
30. Cheng, Ping; Xu, Kuang; Chen, Yan Chi; Wang, Ting Ting; Chen, Yu; Yang, Cheng Long; Ma, Shi Ying; Liang, Yong; Ge, Hui Ming*; Jiao, Rui Hua*. Cytotoxic aromatic polyketides from an insect derived Streptomyces sp. NA4286. Tetrahedron Lett.2019, 60(26): 1706-1709.
31. Shen, Li*; Ai, Chun-Zhi; Song, Yong-Chun; Wang, Feng-Wu; Jiao, Rui-Hua; Zhang, Ai-Hua;, Hui-Zi; Tan, Ren-Xiang*. Cytotoxic Trichothecene Macrolides Produced by the Endophytic Myrothecium roridum. Journal of Natural Products2019, 82 (6): 1503-1509.
32. Han Hao#; Guo Zhi-Kai#; Zhang Bo; Zhang Mei; Shi Jing; Li Wei; Jiao Rui-Hua; Tan Ren-Xiang; Ge Hui-Ming*. Bioactive phenazines from an earwig-associated Streptomyces sp. Chinese Journal of Natural Medicines 2019, 17(6): 475-480.
33. Zhou Zhen-Zhen#; Zhu Hong-Jie#; Yang Cheng-Long; Liu Yan-Jun; Jiang Nan; Xiao Yong-Sheng; Shi Li-Yun; Jiao Rui-Hua; Ge Hui-Ming*; Tan Ren-Xiang*. Dalestones A and B, two anti-inflammatory cyclopentenones from Daldinia eschscholzii with an edited strong promoter for the global regulator LaeA-like gene. Chinese Journal of Natural Medicines 2019, 17(5): 387-393.
34. Liu, Shuang He#; Wang, Wen#; Wang, Kai Biao; Zhang, Bo; Li, Wei; Shi, Jing; Jiao, Rui Hua; Tan, Ren Xiang*; Ge, Hui Ming*. Heterologous Expression of a Cryptic Giant Type I PKS Gene Cluster Leads to the Production of Ansaseomycin. Organic Letters2019, 21(10): 3785-3788.
35. Shi, Jing#; Liu, Cheng Li#; Zhang, Bo; Guo, Wen Jie; Zhu, Jiapeng; Chang, Chin-Yuan; Zhao, Er Juan; Jiao, Rui Hua; Tan, Ren Xiang*; Ge, Hui Ming*. Genome mining and biosynthesis of kitacinnamycins as a STING activator. Chemical Science2019, 10(18): 4839-4846.
36. Zhang, Bo#; Wang, Kai Biao#; Wang, Wen#; Wang, Xin#; Liu, Fang; Zhu, Jiapeng; Shi, Jing; Li, Ling Yu; Han, Hao; Xu, Kuang; Qiao, Hong Yun; Zhang, Xiao; Jiao, Rui Hua; Houk, Kendall N.*; Liang, Yong*; Tan, Ren Xiang*; Ge, Hui Ming*. Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products. Nature2019, 568(7750): 122-126.
37. Yang, Cheng Long#; Wu, Hui Min#; Liu, Cheng Li; Zhang, Xuan; Guo, Zhi Kai; Chen, Yu; Liu, Fang; Liang, Yong; Jiao, Rui Hua; Tan, Ren Xiang; Ge, Hui Ming*. Bialternacins A-F, Aromatic Polyketide Dimers from an Endophytic Alternaria sp. J.Natl. Prod.2019, 82(4): 792-797.
38. Liu, Chengli; Yang, Chenglong; Zeng, Yingjie; Shi, Jing; Li, Lingyu; Li, Wei; Jiao, Ruihua; Tan, Renxiang; Ge, Huiming*.Chartrenoline, a novel alkaloid isolated from a marine Streptomyces chartreusis NA02069. Chin. Chem. Lett.2019, 30(1): 44-46.
39. Zhou, Zhen Zhen#; Zhu, Hong Jie#; Lin, Li Ping; Zhang, Xuan; Ge, Hui Ming; Jiao, Rui Hua; Tan, Ren Xiang*. Dalmanol biosyntheses require coupling of two separate polyketide gene clusters. Chem. Sci. 2019, 10(1): 73-82.
40. Zhu, Zhouting#; Du, Shangce#; Yin, Kai#; Ai, Shichao#; Yu, Mengchao; Liu, Yanqing; Shen, Yan; Liu, Minghui*; Jiao, Ruihua*; Chen, Xi*; Guan, Wenxian*. Knockdown long noncoding RNA nuclear paraspeckle assembly transcript 1 suppresses colorectal cancer through modulating miR-193a-3p/KRAS. Cancer medicine2019, 8(1): 261-275.
2018
41. Zhang, Li; Shi, Jing; Liu, Cheng Li; Xiang, Lang; Ma, Shi Ying; Li, Wei; Jiao, Rui Hua; Tan, Ren Xiang; Ge, Hui Ming.New borrelidin derivatives from an endophytic Streptomyces sp. Tetrahedron Lett.2018, 59(51): 4517-4520.
42. He-Zhong Jiang, Sha Hu, Ren-Xiang Tan, Rui Tan, Rui-Hua Jiao*. Neocucurbitacin D, a novel lactone-type norcucurbitacin as xanthine oxidase inhibitor from Herpetospermum pedunculosum. Natural Product Research, 2018, 34(12):1728-1734.
43. Yi Shuang Wang#, Bo Zhang#, Jiapeng Zhu, Cheng Long Yang, Yu Guo, Cheng Li Liu, Fang Liu, Huiqin Huang, Suwen Zhao, Yong Liang, Rui Hua Jiao, Ren Xiang Tan*, Hui Ming Ge*. Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. Journal of the American Chemical Society2018, 140(34): 10909-10914.
44. Yong Chen, Nan Jiang, Ying Jie Wei, Xiang Li, Hui Ming Ge, Rui Hua Jiao, Ren Xiang Tan*. Citrofulvicin, an Antiosteoporotic Polyketide from Penicillium velutinum. Org. Lett.2018, 20(13): 3741-3744.
45. Sheng Tao Bo, Zi Fei Xu, Li Yang, Ping Cheng, Ren Xiang Tan, Rui Hua Jiao*, Hui Ming Ge*. Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454. Journal of Antibiotic2018, 71(6): 601–605.
46. Bo Zhang, Kai Biao Wang, Wen Wang, Shu Feng Bi, Ya Ning Mei, Xin Zhao Deng,Rui Hua Jiao, Ren Xiang Tan*, and Hui Ming Ge*. Discovery, Biosynthesis, and Heterologous Production of Streptoseomycin, an Anti-Microaerophilic Bacteria Macrodilactone.Org. Lett.2018, 20(10): 2967-2971.
47. Ting Ting Wang, Ying Jie Wei, Hui Ming Ge, Rui Hua Jiao, and Ren Xiang Tan*. Acaulins A and B, Trimeric Macrodiolides from Acaulium sp. H-JQSF. Org. Lett.2018, 20(8): 2490-2493.
48. Wu Sun#, XiaojunWang#, Jialu Li#, Chaoying You#, Pan Lu, Huijin Feng, Yan Kong, Haiyang Zhang, Yanqing Liu, Ruihua Jiao*, Xi Chen* and Yi Ba*. MicroRNA-181a promotes angiogenesis in colorectal cancer by targeting SRCIN1 to promote the SRC/VEGF signaling pathway.Cell Death & Disease 2018, 9: 438.
49. Ting Ting Wang, Ying Jie Wei, Hui Ming Ge, Rui Hua Jiao, and Ren Xiang Tan*. Acaulide, an Osteogenic Macrodiolide from Acaulium sp. H-JQSF, an Isopod-Associated Fungus.Org. Lett.2018, 20(4): 1007-1010.
50. Zhi-Kai Guo#, Yi-Qin Zhou#, Hao Han, Wen Wang, Lang Xiang, Xin-Zhao Deng, Hui-Ming Ge*, Rui-Hua Jiao*. New Antibacterial Phenone Derivatives Asperphenone A–C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1.Mar. Drugs2018, 16(2), 45.
51. Qin-Lan Xu, Yong-Sheng Xiao, Ye Shen, Hui-Min Wu, Xuan Zhang, Xin-Zhao Deng, Ting-Ting Wang, Wei Li, Ren-Xiang Tan, Rui-Hua Jiao*, Hui-Ming Ge*. Novel chaetospirolactone and orsellide F from an endophytic fungus Chaetomium sp.J. Asian Natl. Prod. Res.2018, 20(3): 234-241.
2017
52. Shi Ying Ma, Yong Sheng Xiao, Bo Zhang, Fen Li Shao, Zhi Kai Guo, Juan Juan Zhang, Rui Hua Jiao, Yang Sun, Qiang Xu, Ren Xiang Tan, Hui Ming Ge*. Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete.Organic Letters2017, 19(22): 6208-6211.
53. Ye Shen, Qin Lan Xu, Ping Cheng, Cheng Li Liu, Zhi Yao Lu, Wei Li, Ting Ting Wang, Yan Hua Lu, Ren Xiang Tan, Hui Ming Ge*, Rui Hua Jiao*. Aromatic polyketides from a caterpillar associated Alternaria sp..Tetrahedron Letters2017,58(31): 3069-3072.
54. Cheng-Long Yang, Yi-Shuang Wang, Cheng-Li Liu, Ying-Jie Zeng, Ping Cheng, Rui-Hua Jiao, Shi-Xiang Bao, Hui-Qin Huang*, Ren-Xiang Tan*, Hui-Ming Ge*.Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069.Marine Drugs2017, 15(8). 10.3390/md15080244.
55. Mei Zhang, Cheng Long Yang, Yong Sheng Xiao, Bo Zhang, Xin Zhao Deng, Li Yang, Jing Shi, Yi Shuang Wang, Wei Li, Rui Hua Jiao,Ren Xiang Tan, Hui Ming Ge*. Aurachin SS, a new antibiotic from Streptomyces sp. NA04227. Journal of Antibiotics2017, 70(7): 853-855.
56. Yong Sheng Xiao, Bo Zhang, Mei Zhang, Zhi Kai Guo, Xin Zhao Deng, Jing Shi, Wei Li, Rui Hua Jiao, Ren Xiang Tan*, Hui Ming Ge*. Rifamorpholines A-E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4. Organic & Biomolecular Chemistry. 2017, 15(18): 3909-3916.
57. Wei Yan, Wuringege, Sui-Jun Li, Zhi-Kai Guo, Wen-Jing Zhang, Wei Wei, Ren-Xiang Tan, Rui-Hua Jiao*. New p-terphenyls from the endophytic fungus Aspergillus sp. YXf3. Bioorganic & Medicinal Chemistry Letters2017, 27(1): 51–54.
2016
58. He Zhong Jiang, Rui Tan, Rui Hua Jiao, Xin Zhao Deng, Ren Xiang Tan*. Herpecaudin from Herpetospermum caudigerum, a Xanthine Oxidase Inhibitor with a Novel Isoprenoid Scaffold. Planta Medica2016, 82(11-12): 1122-1127.
59. Liu, C.Q., Jiao, R.H., Yao, L.Y., Zhang, Y.P., Lu, Y.H.*, Tan, R.X.* Adsorption characteristics and preparative separation of chaetominine from Aspergillus fumigatus mycelia by macroporous resin. Journal of Chromatography B-analytical Technologies in the Biomedical and Life Sciences2016, 1015, 135-141.
60. Yao, J.Y.,Jiao, R.H., Liu, C.Q., Zhang, Y.P., Yu, W.G., Lu, Y.H.*, Tan, R.X.* Assessment of the Cytotoxic and Apoptotic Effects of Chaetominine in a Human Leukemia Cell Line. Biomolecules & Therapeutics2016, 24(2): 147-155. MAR 1 2016
61. Yang, J., Jiao, R.H., Yao, L.Y., Han, W.B., Lu, Y.H.*, Tan, R.X.* Control of fungal morphology for improved production of a novel antimicrobial alkaloid by marine-derived fungus Curvularia sp. IFB-Z10 under submerged fermentation. Process Biochemistry2016, 51(2): 185-194.
2015
62. Song, Y.N.; Zhang, W.J.; Bi, S.F.; Jiao, R.H.; Tan, R.X. *; Ge, H.M.* New ansamycin analogues from the mutant strain of Streptomyces seoulensis.Journal of Antibiotics2015, 68(12):757-759. DEC 2015
63. Chen, C.J. ; Zhou, Y.Q. ; Liu, X.X.; Zhang, W.J. ; Hu, S.S. ; Lin, L.P.; Huo, G.M.; Jiao, R.H.; Tan, R.X.*; Ge, H.M.* Antimicrobial and anti-inflammatory compounds from a marine fungus Pleosporales sp.. Tetrahedron Letters 2015, 56(45): 6183-6189. NOV 4 2015
64. Zhu, Y.X. ; Hu, W.W.; Yao, L.Y.; Yu, W.G.; Jiao, R.H.; Lu, Y.H.*; Tan, R.X.* Improvement of fumigaclavine C production in a two-stage culture of Aspergillus fumigatus with molasses as a cost-effective ingredient. Biotechnology and bioprocess Engineering 2015, 20(6):1106-1113.
65. Guo, W.J. 1, Hu, S.S. 1, Elgehama, A., Shao, F.L., Ren, R., Liu, W., Zhang, W.J., Wang, X.L., Tan, R.X., Xu, Q., Sun, Y.*, Jiao, R.H.*Fumigaclavine C ameliorates dextran sulfate sodium-induced murine experimental colitis via NLRP3 inflammasome inhibition. Journal of Pharmacological Sciences2015, 129(2): 101-106.
66. Ren Ren, Wen-Jing Zhang, Xian-Xian Liu, Hui-Ming Ge, Ren-Xiang Tan*, and Rui-Hua Jiao*. Bioactive Trichothecenes Produced by Myrothecium sp. QB-1. Helvetica Chimica Acta2015, 98(10): 1435-1441.
67. Gang Wang#,Jing-Yang Fan#, Wen-Jing Zhang, Cheng-Ping Hua, Chao-Jun Chen, Wei Yan, Rui-Hua Jiao* and Ren-Xiang Tan. Polyketides from mantis-associated fungus Daldinia eschscholzii IFB-TL01.Chemistry & Biodiversity2015, 12(9): 1349-1355.
68. Z. H Pan, R. H. Jiao, Y. H. Lu*, R. X. Tan. Enhancement of dalesconols A and B production via upregulation of laccase antivity by meium optimization and inducer supplementation in submerged fermentation of Daldinia eschscholzii. Bioresource technology 2015, 192: 346-353.
69. Wen Jing Zhang, Wei Wei, Jing Shi, Chao Jun Chen, Guo Yan Zhao, Rui Hua Jiao*, Ren Xiang Tan. Natural Phenolic Metabolites from Endophytic Aspergillus sp. IFB-YXS with Antimicrobial Activity. Bioorganic & Medicinal Chemistry Letters 2015, 25(13):2698-2701.
70. Sha-Sha Hu, Nan-Jiang, Xin-Lei Wang, Chao-Jun Chen, Jing-Yang Fan, Gege-Wurin, Hui-Ming Ge, Ren-Xiang Tan, and Rui-Hua Jiao*. Prenylated diphenyl ethers from the mantis-associated fungus Aspergillus versicolor GH-2. Tetrahedron Letters 2015, 56(25): 3894-3897. JUN 17 2015 NSFC
71. Yao, L.Y.;Zhu, Y.X.; Liu, C.Q.; Jiao, R.H.; Lu, Y.H.*; R. X. Tan*. Preparative separation and purification of fumigaclavine C from fermented mycelia of Aspergillus fumigatus CY018 by macroporous adsorption resin. Journal of Chromatography B2015, 989: 122-128. MAY 1 2015
72. Ren Ren, Chao-Jun Chen, Sha-Sha Hu, Hui-Ming Ge,Wen-Yong Zhu, Ren-Xiang Tan*, Rui-Hua Jiao*. Drimane Sesquiterpenoids from the Aspergillus oryzae QXPC-4. Chemistry & Biodiversity2015, 12(3), 371-379.
73. Song, Ya Nan，Jiao, Rui Hua，Zhang, Wen Jing，Zhao, Guo Yan，Dou, Huan，Jiang, Rong，Zhang, Ai Hua，Hou, Ya Yi，Bi, Shu Feng，Ge, Hui Ming* and Ren Xiang Tan*. New ansamycin derivatives generated by simultaneous mutasynthesis. Organic letters2015,17(3), 556-559. MAR 2015 NSFC
74. Xiu Shi, Wei Wei, Wen-Jing Zhang, Cheng-Pin Hua, Chao-Jun Chen, Hui-Ming Ge, Ren-Xiang Tan and Rui-Hua Jiao*. New tricycloalternarenes from fungus Alternaria sp.J. Asian. Nat. Prod. Res. 2015, 17(2), 143-148. FEB 1 2015NSFC
75. G. Y. Zhao#, J. Y. Fan#, C. P. Hua, W. Yan, C. J. Chen, Y. H. Lu, R H. Jiao*, R. X. Tan*. Resveratrol improves fungal ribosylation capacity through a unique mechanism. RSC Adv. 2015, 5(8), 5657–5663.
2014
76. Wei Yan, Hui Ming Ge, Gang Wang, Nan Jiang, Ya Ning Mei, Rong Jiang, Sui Jun Li, Chao Jun Chen, Rui Hua Jiao, Q. Xu, S. W. Ng, R. X. Tan*. Pictet–Spengler reaction based biosynthetic machinery in fungi. Proc. Natl. Acad. Sci. USA2014, 111(51), 18138–18143.
77. C. J. Chen, R. Jiang, G. Wang, R. H. Jiao, C. Tancharoen, K. Sudto, S. Vajarothi, S. Hannongbua, H. M. Ge*, R. X. Tan*. Oligostibenoids with acetylcholinesterase inhibitory activity from Dipterocarpus alatus. Planta Medica 2014, 80(11), 1641–1646. 2014.11
78. W. Huang, W. J. Zhang, Y. Q. Cheng, R. Jiang, W. Wei, C. J. Chen, G. Wang, R. H. Jiao, R. X. Tan*, H. M. Ge*. Cytotoxic and antimicrobial flavonoids from Cryptocarya concinna. Planta Medica 2014, 80（11）, 925–930. 2014.7
79. L.Y. Yao, Y, X. Zhu, R. H. Jiao, Y. H. Lu*, R. X. Tan*. Enhanced production of fumigaclavine C by ultrasound stimulation in a two-stage culture of Aspergillus fumigatus CY018. Bioresource Technol.2014, 159, 112–117. MAY 2014
80. Y. X. Zhu, L. Y. Yao, R. H. Jiao, Y. H. Lu*, R. X. Tan*. Enhanced production of fumigaclavine C in liquid culture of Aspergillus fumigatus under a two-stage process.Bioresource Technol.2014, 152, 162–168. JAN 2014
81. Jia-Jia Liu#,Juan Sun#,Yun-Bin Fang, Yong-An Yang,* Rui-Hua Jiao* andHai-Liang Zhu*. Synthesis, and antibacterial activity of novel4,5-dihydro-1H-pyrazole derivatives as DNAgyrase inhibitors. Organic &Biomolecular Chemistry2014,12（6）, 998-1008.
2013
82. Wuringege, Z. K. Guo, W. Wei, R. H. Jiao, T. Yan, L. Y. Zang, R. Jiang, R. X. Tan, H. M. Ge*. Polyketides from the plant endophytic fungus Cladosporium sp. IFB3lp-2. J. Asian. Nat. Prod. Res. 2013,15(9), 928–933.
83. S. F. Bi, Z. K. Guo, N. Jiang, R. H. Jiao, H. M. Ge, R. X. Tan*. New alkaloid from Streptomyces koyangensis residing in Odontotermes formosanus. J. Asian. Nat. Prod. Res. 2013, 15(4), 422–425.(IF=1.091)
84. R. H. Jiao, H. Xu, J. T. Cui, H. M. Ge, R. X. Tan*. Neuraminidase Inhibitors from marine-derived actinomycete Streptomyces seoulensis. J. Appl. Microbiol. 2013, 114(4), 1046–1053. (IF=2.658)
85. T. Yan, Z. K. Guo, R. Jiang, W. Wei, T. Wang, Y. Guo, Y. C. Song, R. H. Jiao, R. X. Tan, H. M. Ge*. New flavonol and diterpenoids from the endophytic fungus Aspergillus sp. YXf3. Planta Medica 2013,79(5), 348–352. MAR 2013
86. Z. K. Guo, R. H. Jiao, H. F. Dai, W. L. Mei, R. X. Tan∗, H. M. Ge∗. Actinotetraoses I-K, tetrasaccharide metabolites produced by an insect-der actinobacterium Amycolatopsis sp. HCa1. Chem. Biodivers. 2013, 10(2), 296–302.
2012
87. Z. K. Guo, S. B. Liu, R. H. Jiao, T. Wang, R. X. Tan∗, H. M. Ge∗. Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity. Bioorg. Med. Chem. Lett. 2012, 22(24), 7490–7493.
88. Zang, Le Yun; Wei, Wei; Guo, Ye; Wang, Ting; Jiao, Rui Hua; Ng, Seik; Tan, Ren Xiang; Ge, Hui Ming∗. Sesquiterpenoids from the Mangrove Derived Endophytic Fungus Diaporthe sp.Journal of Natural Products 2012, 75(10): 1744-1749. (IF=3.164)
89. Guo, Zhi Kai, Zhang, Gao Fei, Jiao, Rui Hua, Shen, Yan, Xu, Qiang, Tan, Ren Xiang, Ge, Hui Ming*. Actinotetraoses A-H: Tetrasaccharide Derivatives from a Grasshopper-Associated Amycolatopsis sp. HCa1. Planta Medica 2012, 78(10): 988-994. (IF=2.338)
90. Z. K. Guo, T. Yan, Y. Guo, Y. C. Song, R. H. Jiao, R. X. Tan, H. M. Ge*. p-Terphenyl and diterpenoid metabolites from endophytic Aspergillus sp. YXf3. J. Nat. Prod. 2012, 75(1), 15−21.
2011年及以前
91. H. Xu, N. Jiang, Y. Guo, R. H. Jiao, J. T. Cui, Y. C. Song, R. X. Tan. Fully substituted unsaturated lactones from endophytic Myrothecium sp. J. Asian Nat. Prod. Res. 2011, 13(11), 1003–1007.
92. H. M. Ge, W. Yan, Z. K. Guo, Q. Luo, R. Feng, L. Y. Zang, Y. Shen, R. H. Jiao, Q. Xu, Ren Xiang Tan*. Precursor-directed Q1 fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. Chem. Commun.2011, 47(8), 2321–2323.
93. J. Zhang, H. M. Ge, R. H. Jiao, J. Li, H. Peng, Y. R. Wang, J. H. Wu, Y. C. Song, R. X. Tan*. Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. Planta Medica 2010, 76（16）, 1910–1914.
94. Hui Ming Ge, Rui Hua Jiao, Yu Fei Zhang, Jie Zhang, Yu Rong Wang, Ren Xiang Tan*. Cytotoxicity and Phytotoxicity of Trichothecene Macrolides from Myrothecium gramminum. Planta Medica 2009, 75（3）: 227–229. (IF=2.338)
95. F. W. Wang. R. H. Jiao, A. B. Cheng, Y. C. Song*. Antimicrobial potentials of endophytic fungi residing in Quercus variabilis. World Journal of Microbiology & Biotechnology2007, 23 (1): 79-83. (IF=1.602)
96. Jiao R. H., Xu S., Liu J. Y., Tan R. X*. Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Organic Letters 2006,8(25): 5705-5708.
97. Li Shen†, Rui H. Jiao†, Yong H. Ye, Xiao T. Wang, Chen Xu, Yong C. Song, Hai L. Zhu, and Ren X. Tan*. Absolute configuration of new cytotoxic and other bioactive trichothecene macrolides. Chemistry, A European journal 2006, 12: 5596-5602.
98. Rui H. Jiao, Hui M. Ge, Da H. Shi, Ren X. Tan*. An Apigenin-Derived Xanthine Oxidase Inhibitor from Palhinhaea cernua.Journal of natural Products 2006, 69(7): 1089-1091.
99. Feng-Wu Wang, Rui-Hua Jiao, Ren-Xiang Tan, Hai-Liang Zhu and Edward R. T. Tiekink. 1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methylprop-1-enyl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino [1',2':1,6] pyrido[3,4-b]indole-5,14-dione. Acta Crystallographica Section E. 2006, E62: o1375–o1377.
100. Wen-Zheng Ju, Rui-Hua Jiao, Ping Cao and Rui-Qin Fang. Bis(2-aminopyridine)dibenzoatocobalt(II). Acta Crystallographica Section E. 2006, E62: m1012–m1013. （IF=0.581）MAY 2006
101. 焦瑞华，郁文，朱晓雪. 浅论中国大学志愿文化的构建和发展，高教研究与探索，2010, 3-4:111-113.
主持在研项目:
1、海洋微生物先导化合物的生物合成调控与产率优化，国家863计划海洋技术领域主题项目
2、海洋共生微生物先导化合物的发现与优化，国家863计划海洋技术领域主题项目（共同主持）
3、共生真菌产生的新型抗病原菌化合物的发现与作用机制研究，江苏省基金面上项目