新闻动态
2024-10-20Zhao LY, Shi J*, Xu ZY, Sun JL, Yan ZY, Tong ZW, Tan RX, Jiao RH*, Ge HM*. Hybrid Type I and II Polyketide Synthases Yield Distinct Aromatic Polyketides. J. Am. Chem. Soc. 2024, 146, 29462−29468.
2024-07-10Mai ZP, Zhang B*, Pang ZX, Shi J, Xu ZF, Huang BB, Ma SY, Jiao RH, Yao ZJ, Tan RX*, Ge HM*.Insight into the role of a trans-AT polyketide synthase in the biosynthesis of lankacidin-type natural products. Nat. Synth. 2024, 3, 1255–1265.
2024-05-24祝贺赵丽娅博士顺利通过博士学位论文答辩！！！
2024-05-24祝贺彭婷硕士、管冬梅硕士顺利通过硕士学位论文答辩！！！
2023-12-12Liu CL, Wang ZJ, Shi J*, Yan ZY, Zhang GD, Jiao RH, Tan RX, Ge HM*. P450-Modified Multicyclic Cyclophane-Containing Ribosomally Synthesized and Post-Translationally Modified Peptides. Angew. Chem. Int. Ed. 2024, 63, e202314046.
2023-12-09Hu YL, Yin FZ, Shi J, Ma SY, Wang ZR, Tan RX, Jiao RH*, Ge HM*. P450-Modified Ribosomally Synthesized Peptides with Aromatic Cross-Links. J. Am. Chem. Soc. 2023.
2023-10-23Xu ZF, Zhou YL, Bo ST, Zhang SQ, Shi J, Xiang L, Xi MY, Zhang B, Xu ZR, Yang D, Shen B, Tan RX*, Ge HM*. Discovery and biosynthetic pathway analysis of cyclopentane–β-lactone globilactone A. Nat. Synth. 2023.
2023-10-07Zhang L, Zhang B*, Zhu A, Liu SH, Wu R, Zhang X, Xu ZR, Tan RX, Ge HM*. Biosynthesis of Phomactin Platelet Activating Factor Antagonist Requires a Two-Enzyme Cascade. Angew. Chem. Int. Ed. 2023, 62, e20231299.
2023-08-10首届国际天然产物研究黄山论坛圆满落幕！！！
2023-05-26祝贺刘程丽博士、张丽博士、胡逸灵博士顺利通过博士学位论文答辩！！！
2023-05-25祝贺孙佳丽硕士、张琪硕士、尤雪婷硕士、凌清彦硕士、贺文硕士顺利通过硕士学位论文答辩！！！
2023-04-282023年暖春团建留影！
2023-03-08Hu YL, Zhang Q, Liu SH, Sun JL, Yin FZ, Wang ZR, Shi J, Jiao RH*, Ge HM*. Building Streptomyces albus as a Chassis for Synthesis of Bacterial Terpenoids. Chem. Sci. 2023.
2023-02-21Zhang B, Ge HM*. Selective cycloadditions. Nat. Chem. 2023, 15, 167-169.
2023-02-09Xiang L, Shi J, Zhu A, Xu ZF, Liu SH, Wang YS, Guo ZK, Jiao RH, Tan RX*, Ge HM*. Total Biosynthesis of Mutaxanthene Unveils a Flavoprotein Monooxygenase Catalyzing Xanthene Ring Formation. Angew. Chem. Int. Ed. 2023, e202218660.
2023-01-04Yang YM, Zhao EJ, Wei WQ, Xu ZF, Shi J, Wu X, Zhang B, ..., Jiao RH*, Liang Y*, Tan RX, Ge HM*. Cytochrome P450 Catalyzes Benzene Ring Formation in the Biosynthesis of Trialkyl-Substituted Aromatic Polyketides. Angew. Chem. Int. Ed. 2022, e202214026.
2022-11-08Li LY, Hu YL, Sun JL, Yu LB, Shi J, Wang ZR, Guo ZK, Zhang B, Guo WJ, Tan RX*, Ge HM*. Resistance and phylogeny guided discovery reveals structural novelty of tetracycline antibiotics. Chem. Sci. 2022,13, 12892-12898.
2022-11-02Zhang B, Ge HM*. Pericyclases for cycloaddition. Natl. Sci. Rev. 2022, 9, nwac229.
2022-10-11欢迎杨祉偎、庞子萱、袁澄源、徐朝阳、陈君尧加入研究所进入硕士阶段的学习！！！
2022-09-19欢迎董慧雯、王思媛、陈婉欣、曾麒、黄晓玲、金川博加入研究所进入博士阶段的学习！！！
2022-09-06祝贺李玲玉博士、向浪博士、赵阳博士、杨雨蒙博士顺利通过博士学位论文答辩！！！
2022-08-08Zhao Y, Zhang B, Sun ZQ, Zhang H, Wang W, Wang ZR, Guo ZK, Yu SY*, Tan RX*, Ge HM*. Biocatalytic C14-Hydroxylation on Androstenedione Enabled Modular Synthesis of Cardiotonic Steroids. ACS Catal. 2022, 12, 9839–9845.
2022-08-08Zhu HJ, Zhang B, Wei WQ, Liu SH, Xiang L, Zhu JP, Jiao RH, …, Liang Y*, Tan RX*, Ge HM*. AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis. Nat. Commun. 2022, 13, 4499.
2022-06-18Liu SH, Sun JL, Hu YL, Zhang L, Zhang X, Yan ZY, Guo X, Guo ZK, Jiao RH, Zhang B*, Tan RX*, Ge HM*.Biosynthesis of Sordarin Revealing a Diels-Alderase for the Formation of the Norbornene Skeleton. Angew. Chem. Int. Ed. 2022, 61, e202205577.
2022-06-18祝贺Salman博士顺利通过博士学位论文答辩！！！
2022-06-18祝贺王勇超硕士、施阳硕士、孙子茜硕士、李键成硕士、王岚硕士顺利通过硕士学位论文答辩！！！
2022-04-27Shi J, Shi Y, Li JC, Wei WQ, Chen Y, Cheng P, … , Zhang B, Jiao RH, Yu SY, Liang Y*, Tan RX*, Ge HM*. In Vitro Reconstitution of Cinnamoyl Moiety Reveals Two Distinct Cyclases for Benzene Ring Formation. J. Am. Chem. Soc. 2022, 144, 17, 7939–7948.
2022-01-242022年新春掼蛋比赛圆满落幕！！！
2021-12-25祝贺我所公众号：南大IFB关注人数突破5000人！！！
2021-12-16Wang X, Zhang C, Jiang YYK, … , Zhang B, Tan RX, Ge HM*, Yang ZY*, Liang Y*. Influence of Water and Enzyme on the Post-Transition State Bifurcation of NgnD-Catalyzed Ambimodal [6+4]/[4+2] Cycloaddition. J. Am. Chem. Soc. 2021, 143, 49, 21003–21009.
2021-10-22欢迎孙嘉霖、朱傲、张毅、管东梅、王子杰、彭婷、周叶蕾加入研究所进入硕士阶段的学习！！！
2021-10-09欢迎殷方洲、邹丹丹、谭雯斐、宋强、郭浩、张晨鹏加入研究所进入博士阶段学习！！！
2021-09-30Jiao FW, Wang YS, You XT, … , Zhang B, Liang Y*, Tan RX*, Jiao RH*, Ge HM*. An NADPH-dependent Ketoreductase Catalyses the Tetracyclic to Pentacyclic Skeletal Rearrangement in Chartreusin Biosynthesis. Angew. Chem. Int. Ed. 2021, 60, 26378-26384.
2021-08-30祝贺朱宏杰博士、焦方文博士、童志武博士、王文博士、刘双鹤博士顺利通过博士学位论文答辩！！！
2021-06-30Tong ZW, Xie XH, Wang TT, Lu M, Jiao RH, Ge HM, Hu G*, Tan RX*. Acautalides A–C, Neuroprotective Diels–Alder Adducts from Solid-State Cultivated Acaulium sp. H-JQSF. Org. Lett. 2021, 23, 5587–5591.
2021-05-28祝贺樊瑞硕士、刘珮熠硕士、徐响硕士、马嘉琪硕士、魏园园硕士、邢银南硕士、吴锐硕士顺利通过硕士学位论文答辩！！！
2021-04-20Liu SH, Wei YY, Xing YN, Chen Y, Wang W, Wang KB, Liang Y, Jiao RH, Zhang B, Ge HM. A BBE-like Oxidase, AsmF, Dictates the Formation of Naphthalenic Hydroxyl Groups in Ansaseomycin Biosynthesis. Org. Lett. 2021, 23, 3724–3728.
2021-04-07Wang KB, Wang W, Zhang B, Wang X, Chen Y, Zhu HJ, Liang Y, Tan RX, Ge HM. A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis. Nat. Commun. 2021,12, 2092.
2021-03-31Zhu HJ, Zhang B, Wang L, Wang W, Liu SH, Igarashi Y, Bashiri G, Tan RX, Ge HM. Redox Modifications in the Biosynthesis of Alchivemycin A Enable the Formation of Its Key Pharmacophore. J. Am. Chem. Soc. 2021, 143, 4751-4757.
2021-01-05Jing Shi, Xiang Xu, Pei Yi Liu, Yi Ling Hu, Bo Zhang, Rui Hua Jiao, Ghader Bashiri, Ren Xiang Tan, Hui Ming Ge. Discovery and biosynthesis of guanipiperazine from a NRPS-like pathway. Chem. Sci. 2021, 12, 2925-2930.
2020-10-202020年金秋团建留影！
2020-10-01欢迎孙佳丽，尤雪婷，张琪，贺文，凌清彦加入研究所进入硕士阶段学习！！
2020-09-24祝贺我所公众号： 南大IFB 关注人数突破2000人！！！
2020-09-15欢迎邹妍，张国栋，奚萌宇，王子儒，颜樟元，郭兴，艾丽曼，赵尔娟加入研究所进入博士阶段学习！！
2020-08-11Zi Fei Xu, Sheng Tao Bo, Mei Jing Wang, Jing Shi, Rui Hua Jiao, Yang Sun, Qiang Xu, Ren Xiang Tan and Hui Ming Ge. Discovery and biosynthesis of bosamycins from Streptomyces sp. 120454. Chem. Sci. 2020, 11, 9237-9245.
2020-08-01祝贺李伟博士、徐梓斐博士顺利通过博士学位论文答辩！！！
2020-06-19Yang CL, Zhang B, Xue WW, Li W, Xu ZF, Shi J, Shen Y, Jiao RH, Tan RX, Ge HM. Discovery, Biosynthesis, and Heterologous Production of Loonamycin, a Potent Anticancer Indolocarbazole Alkaloid. Org. Lett. 2020, 22, 4665-4669.
2020-05-29祝贺朱梦月硕士、卫静硕士、陈道印硕士、谭英姿硕士、王佳琦硕士顺利通过硕士学位论文答辩！！！
2020-01-14Dai GZ, Han WB, Mei YN, Xu K, Jiao RH, Ge HM, Tan RX. Pyridoxal-5'-phosphate-dependent bifunctional enzyme catalyzed biosynthesis of indolizidine alkaloids in fungi. Proc. Natl. Acad. Sci. USA. 2020, 117, 1174-1180.
2019-09-01欢迎王岚，李键成，王勇超，孙子茜，施阳，刘程丽，张丽、赵丽娅加入研究所进入硕士或博士阶段学习！！
2019-08-15Shuanghe Liu, Wen Wang, Kaibiao Wang, Bo Zhang, Wei Li, Jing Shi, Ruihua Jiao, Renxiang Tan, Huiming Ge. Heterologous Expression of a Cryptic Giant Type I PKS Gene Cluster Leads to the Production of Ansaseomycin. Org. Lett. 2019, 21, 3785-3788.
2019-08-15Jing Shi, Xiang Xu, Er Juan Zhao, Bo Zhang, Wei Li, Yang Zhao, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge. Genome Mining and Enzymatic Total Biosynthesis of Purincyclamide. Org. Lett. 2019, 21, 6825–6829.
2019-07-22功能生物分子研究所成员参加“第四届放线菌生物学暨第二届微生物药物学术研讨会”留影
2019-05-28祝贺史净博士、王凯标博士顺利通过博士学位论文答辩！！！
2019-05-24祝贺曾莹杰、韩浩、马仕英、程屏、陈彦炽、许旷、张丽和刘程丽顺利通过硕士学位论文答辩！！！
2019-04-01Jing Shi, Cheng Li Liu, Bo Zhang, et al. Ren Xiang Tan and Hui Ming Ge Genome mining targeting unique type II PKS and NRPS led to the identification of a novel class of glycopeptides named kitacinnamycins. Chem. Sci. 2019, 10, 4839-4846.
2019-03-19Zhang B, Wang KB, Wang W, Wang X, Liu F, Zhu J, Shi J, Li LY, Han H, Xu K, Qiao HY, Zhang X, Jiao RH, Houk KN, Liang Y, Tan RX, Ge HM. Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products. Nature 2019, 568, 122-126.
2019-01-21Jing Shi, Ying Jie Zeng, Bo Zhang, et al. Ren Xiang Tan, and Hui Ming Ge Comparative Genome Mining and Heterologous Expression of an Orphan NRPS Gene Cluster Directs the Production of Ashimides. Chem. Sci. 2019, 10, 3042-3048.
2018-12-19Li Zhang, Jing Shi, Cheng Li Liu , Lang Xiang , Shi Ying Ma, Wei Li a, Rui Hua Jiao ,Ren Xiang Tan, Hui Ming Ge New borrelidin derivatives from an endophytic Streptomyces sp. Tetrahedron Lett. 2018, 59, 4517-4520.
2018-11-27Zhen Zhen Zhou, Hong Jie Zhu, Li Ping Lin, Xuan Zhang, Hui Ming Ge, Rui Hua Jiao, Ren Xiang Tan. Dalmanol biosyntheses require coupling of two separate polyketide gene clusters. Chem. Sci., 2019, 10, 73-82.
2018-11-26Chengli Liu, Chenglong Yang, Yingjie Zeng, Jing Shi, Lingyu Li, Wei Li, Ruihua Jiao,Renxiang Tan, Huiming Ge Chartrenoline, a novel alkaloid isolated from a marine Streptomyces chartreusis NA02069. Chinese Chem. Lett. 2019, 30, 44-46.
2018-11-24祝贺王以爽同学顺利通过博士学位论文答辩！！
2018-09-10欢迎吴锐，徐响，邢银南，魏园园，马嘉琪，樊瑞，刘珮熠，赵尔娟，杨雨蒙，王文，朱宏杰，童志武，胡逸灵加入研究所进入硕士或博士阶段学习！！
2018-08-17Yi Shuang Wang, Bo Zhang, Jiapeng Zhu, et al. Ren Xiang Tan, Hui Ming Ge. Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. J. Am. Chem. Soc. 2018, 140, 10909–10914.
2018-05-27祝贺张璇、张蕾、王婷婷、代广知四位同学顺利通过博士学位论文答辩！
2018-05-25祝贺薄胜涛、杨丽、杨成龙三位同学顺利通过硕士学位论文答辩！
2018-05-25欢迎邢银南同学入组进行本科毕设和研究生学习！
2018-05-24Xuan Zhang, Ting Ting Wang, Qin Lan Xu, ..., Qiang Xu, Ren Xiang Tan, Hui Ming Ge. Genome Mining and Comparative Biosynthesis of Meroterpenoids from Two Phylogenetically Distinct Fungi. Angew. Chem. Int. Ed. 2018, 57, 8184-8188.
2018-04-28Bo Zhang∥, Kai Biao Wang∥, Wen Wang, .. Rui Hua Jiao, Ren Xiang Tan,* Hui Ming Ge* Discovery, Biosynthesis, and Heterologous Production of Streptoseomycin, an Anti-Microaerophilic Bacteria Macrodilactone. Org. Lett., 2018, 20, 2967
2018-04-02 Ting Ting Wang, Ying Jie Wei, Hui Ming Ge, Rui Hua Jiao, and Ren Xiang Tan* Acaulide, an Osteogenic Macrodiolide from Acaulium sp. H-JQSF, an Isopod-Associated Fungus. Org. Lett., 2018, 20, pp 1007–1010
2018-03-01Ting Ting Wang, Ying Jie Wei, Hui Ming Ge, Rui Hua Jiao, and Ren Xiang Tan* Acaulins A and B, Trimeric Macrodiolides from Acaulium sp. H-JQSF. Org. Lett., 2018, 20, 2490–2493
2017-11-23欢迎美国Scripps研究所徐正仁博士以及中国热带农业科学院郭志凯博士来我所参观交流
2017-11-14 Shi Ying Ma,† Yong Sheng Xiao,† Bo Zhang,† et al., Ren Xiang Tan,* and Hui Ming Ge* Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete. Org. Lett., 2017, 19, 6208–6211
2017-10-08欢迎生科院徐响和化院杨佳进入研究所进行毕设。
2017-09-01欢迎新成员刘双鹤、焦方文、王凤、谭英姿、陈道印、王佳琦、朱梦月、卫静加入研究所进入博士或硕士阶段学习。
2017-03-12Ai Hua Zhang, Wen Liu, Nan Jiang, Qiang Xu, and Ren Xiang Tan. Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor. Org. Lett., 2016, 18, 6496–6499.
2016-09-02欢迎赵阳、向浪、李玲玉、曾莹杰、韩浩、马仕英、程屏、陈彦炽、王文、许旷、张丽和刘程丽加入研究所进入直博或硕士阶段学习！
2016-06-22欢迎史净、徐梓斐加入研究所进入博士阶段学习。
2016-05-25祝贺史净、李随军、马振军、曹江明、刘贤贤、肖春城硕士论文答辩成功！
2016-05-06Wen Bo Han, Ai Hua Zhang, Xin Zhao Deng, Xinxiang Lei, and Ren Xiang Tan* Curindolizine, an Anti-Inflammatory Agent Assembled via Michael Addition of Pyrrole Alkaloids Inside Fungal Cells Org. Lett., 2016, 18, 1816–1819
2016-05-06Angew.Chem.Int. Ed. 2016, 55,3690 –3693.
2016-04-14Org. Lett., 2015, 17, 556–559.
2016-03-05Org. Lett. 2015, 17, 1457–1460.
2016-03-03欢迎赵阳、向浪、李玲玉、马仕英、涂庭月、曾莹杰加入研究所
2016-03-01Org. Lett., 2014, 16, 5366–5369
2016-03-01Proc. Natl. Acad. Sci. USA 2014, 111, 18138–18143.