焦瑞华

副教授、硕士生导师

办公地点:生科楼A408

Emailrhjiao@nju.edu.cn


学习和进修经历

    2011.03  香港理工大学  专题研习班

    2001.9.01-2006.6.20 南京大学 理学博士(硕博连读)

工作经历

    2011年        南京大学“青年骨干教师”

    2009.12.01-至今  南京大学生命科学学院       副教授

    2006.8 -2009.12  南京大学生命科学学院       讲师


获奖情况

2007年  植物内生真菌代谢物研究教育部2007年度高等学校科学技术奖自然科学奖一等奖,第四完成人

2007年  江苏省优秀博士论文

2006年  美国“百人会”英才奖


学术兼职

 12011至今中国微生物学会海洋微生物学专业委员会    委员


学术论文

 2016

  1. Liu, C.Q., Jiao, R.H., Yao, L.Y.,Zhang, Y.P.,  Lu, Y.H., Tan, R.X. Adsorption characteristics and preparative separation of chaetominine from Aspergillus fumigatus mycelia by macroporous resin. Journal of Chromatography B-analytical Technologies in the Biomedical and Life Sciences 2016, 1015: 135-141.

  2. Yao, J.Y., Jiao, R.H., Liu, C.Q., Zhang, Y.P., Yu, W.G., Lu, Y.H., Tan, R.X. Assessment of the Cytotoxic and Apoptotic Effects of Chaetominine in a Human Leukemia Cell Line. Biomolecules & Therapeutics 2016, 24(2): 147-155.

  3. Yang, J., Jiao, R.H., Yao, L.Y.,  Han, W.B., Lu, Y.H., Tan, R.X.Control of fungal morphology for improved production of a novel antimicrobial alkaloid by marine-derived fungus Curvularia sp. IFB-Z10 under submerged fermentation. Process Biochemistry 2016, 51(2): 185-194.

  4. Yao, J.Y.;Jiao, R.H.; Liu, C.Q.; Zhang,Y.P.; Yu,W.G.; Lu, Y.H*; Tan, R.X.* Assessment of the Cytotoxic and Apoptotic Effects of Chaetominine in a Human Leukemia Cell Line. Biomol. Ther.2016, 24(2):147-155.

2015

  1. Song, Y.N.; Zhang, W.J.; Bi, S.F.; Jiao, R.H.; Tan, R.X. *; Ge, H.M. *New ansamycin analogues from the mutant strain of Streptomyces seoulensis.Journal of Antibiotics 2015, 68(12):757-759.

  2. Chen, C.J. ; Zhou, Y.Q. ; Liu, X.X.; Zhang, W.J. ; Hu, S.S. ; Lin, L.P.; Huo, G.M.; Jiao,R.H.; Tan, R.X.*; Ge, H.M.*Antimicrobial and anti-inflammatory compounds from a marine fungus Pleosporales sp..Tetrahedron Letters 2015, 56(45): 6183-6189.

  3. Zhu, Y.X. ; Hu, W.W.; Yao, L.Y.; Yu, W.G.; Jiao, R.H.; Lu, Y.H.*; Tan, R.X.* Improvement of fumigaclavine C production in a two-stage culture of Aspergillus fumigatus with molasses as a cost-effective ingredient. Biotechnology and bioprocess Engineering 2015, 20(6):1106-1113.

  4. Guo, W.J., Hu, S.S., Elgehama, A., Shao, F.L., Ren, R., Liu, W., Zhang, W.J., Wang, X.L., Tan, R.X., Xu, Q., Sun, Y.*, Jiao, R.H.* Fumigaclavine C ameliorates dextran sulfate sodium-induced murine experimental colitis via NLRP3 inflammasome inhibition. Journal of Pharmacological Sciences 2015, 129(2): 101-106

  5.  Ren Ren, Wen-Jing Zhang, Xian-Xian Liu, Hui-Ming Ge, Ren-Xiang Tan*, and Rui-Hua Jiao*. Bioactive Trichothecenes Produced by Myrothecium sp. QB-1. Helvetica Chimica Acta 2015, 98(10): 1435-1441.  

  6.  Gang Wang,Jing-Yang Fan, Wen-Jing Zhang, Cheng-Ping Hua, Chao-Jun Chen, Wei Yan, Rui-Hua Jiao* and Ren-Xiang Tan. Polyketides from mantis-associated fungus Daldiniaeschscholzii IFB-TL01.Chemistry & Biodiversity2015, 12(9): 1349-1355.

  7. Z. H Pan, R. H. Jiao, Y. H. Lu*, R. X. Tan*. Enhancement of dalesconols A and B production via upregulation of laccase antivity by meium optimization and inducer supplementation in submerged fermentation of Daldinia eschscholzii. Bioresource technology 2015, 192: 346-353.

  8.  Wen Jing Zhang, Wei Wei, Jing Shi, Chao Jun Chen, Guo Yan Zhao, Rui Hua Jiao*, Ren Xiang Tan. Natural Phenolic Metabolites from Endophytic Aspergillus sp. IFB-YXS with Antimicrobial Activity. Bioorganic & Medicinal Chemistry Letters 2015, 25(13):2698-2701.

  9.  Sha-Sha Hu, Nan-Jiang,Xin-Lei Wang, Chao-Jun Chen, Jing-Yang Fan, Gege-Wurin,Hui-Ming Ge, Ren-Xiang Tan, and Rui-Hua Jiao*. Prenylated diphenyl ethers from the mantis-associated fungus Aspergillus versicolor GH-2. Tetrahedron Letters2015, 56(25): 3894-3897.

  10.  Yao, L. Y.; Zhu, Y. X.; Liu, C. Q.; Jiao, R. H.;Lu, Y, H.*; R. X. Tan*. Preparative separation and purification of fumigaclavine C from fermented mycelia of Aspergillus fumigatus CY018 by macroporous adsorption resin. J Chromatogr B2015, 989: 122-128.  

  11.  Ren Ren, Chao-Jun Chen, Sha-Sha Hu, Hui-Ming Ge, Wen-Yong Zhu, Ren-Xiang Tan*, Rui-Hua Jiao*. Drimane Sesquiterpenoids from the Aspergillus oryzae QXPC-4. Chemistry & Biodiversity2015, 12(3), 371-379.

  12. Song, Ya NanJiao, Rui HuaZhang, Wen JingZhao, Guo YanDou, HuanJiang, RongZhang, Ai HuaHou, Ya YiBi, Shu FengGe, Hui Ming. New ansamycin derivatives generated by simultaneous mutasynthesis. Organic letters2015,17(3):556-559.

  13.  Xiu Shi, Wei Wei, Wen-Jing Zhang, Cheng-Pin Hua, Chao-Jun Chen, Hui-Ming Ge, Ren-Xiang Tan and Rui-Hua Jiao*. New tricycloalternarenes from fungus Alternaria sp. J. Asian. Nat. Prod. Res. 2015, 17(2), 143-148.

  14. G. Y. Zhao, J. Y. Fan,C. P. Hua, W. Yan, C. J. Chen,Y. H. Lu, RH. Jiao*, R. X. Tan*.Resveratrol improves fungal ribosylation capacitythrough a unique mechanism. RSC Adv. 2015, 5(8), 5657–5663.


2014

  1. Wei Yan, Hui Ming Ge, Gang Wang, Nan Jiang, Ya Ning Mei, Rong Jiang, Sui Jun Li, Chao Jun Chen, Rui Hua Jiao, Q. Xu, S. W. Ng, R. X. Tan*. Pictet–Spenglerreaction based biosynthetic machinery in fungi. Proc.Natl. Acad. Sci. USA2014, 11151, 18138–18143.

  2. C. J. Chen, R.Jiang, G. Wang, R. H. Jiao, C.Tancharoen, K. Sudto, S. Vajarothi, S.Hannongbua, H. M. Ge*, R. X. Tan*.Oligostibenoids with acetylcholinesterase inhibitory activity from Dipterocarpus alatus.Planta Med.2014, 8011,16411646.

  3. W. Huang, W. J. Zhang, Y. Q. Cheng, R. Jiang, W. Wei, C. J. Chen, G. Wang, R. H. Jiao, R. X. Tan*, H. M. Ge*. Cytotoxic and antimicrobial flavonoids from Cryptocarya concinna.Planta Med.2014, 8011, 925–930.

  4. Y. X. Zhu, L. Y. Yao, R. H. Jiao, Y. H. Lu*, R. X. Tan*. Enhanced production of fumigaclavine C in liquid culture of Aspergillusfumigatus under a two-stage process. Bioresource Technol.2014, 152, 162168.

  5. Y. Yao, Y, X. Zhu, R. H. Jiao, Y. H. Lu*, R. X. Tan*. Enhanced production of fumigaclavine C by ultrasound stimulation in a two-stage culture of Aspergillus fumigatus CY018. Bioresource Technol.2014, 159,112–117.


2013

  1. Wuringege, Z. K. Guo, W. Wei, R. H. Jiao, T. Yan, L. Y. Zang,R. Jiang, R. X. Tan, H. M. Ge*. Polyketides from the plant endophytic fungusCladosporium sp. IFB3lp-2. J. Asian. Nat. Prod. Res. 2013, 15(9), 928–933.

  2. S. F. Bi, Z. K. Guo, N. Jiang, R. H. Jiao, H. M. Ge, R. X. Tan*. New alkaloid from Streptomyces koyangensis residing in Odontotermes formosanus. J. Asian. Nat. Prod. Res. 2013, 15(4), 422425.

  3. R. H.Jiao, H. Xu, J. T.Cui,H. M. Ge, R. X. Tan*. Neuraminidase Inhibitors from marine-derived actinomycete Streptomyces seoulensis. J. Appl. Microbiol. 2013, 114(4), 10461053.

  4. T. Yan, Z. K. Guo, R. Jiang, W. Wei, T. Wang, Y. Guo, Y. C. Song, R. H. Jiao, R. X. Tan, H. M. Ge*. New flavonol and diterpenoids from the endophytic fungus Aspergillus sp.YXf3. Planta Med. 2013, 79(5), 348352.

  5. Z. K. Guo, R. H. Jiao, H. F. Dai, W. L.Mei, R. X. Tan, H. M. Ge. Actinotetraoses I-K, tetrasaccharide metabolites produced by an insect-der actinobacterium Amycolatopsis sp.HCa1. Chem.Biodivers. 2013, 10(2),296–302.


2012

  1. Z. K. Guo, S. B. Liu, R. H. Jiao, T. Wang, R. X. Tan, H. M. Ge. Angucyclines from an insect-derived actinobacterium Amycolatopsis sp.HCa1 and their cytotoxic activity. Bioorg. Med. Chem. Lett. 2012, 22(24), 74907493.

  2.  Zang, Le Yun; Wei, Wei; Guo, Ye; Wang, Ting; Jiao, Rui Hua; Ng, Seik; Tan, Ren Xiang; Ge, Hui Ming. Sesquiterpenoids from the Mangrove Derived Endophytic Fungus Diaporthe sp.Journal of Natural Products2012, 75(10): 1744-1749.  

  3.  Guo, Zhi Kai, Zhang, Gao Fei, Jiao, Rui Hua, Shen, Yan,  Xu, Qiang,  Tan, Ren Xiang, Ge, Hui Ming.  Actinotetraoses A-H: Tetrasaccharide Derivatives from a Grasshopper-Associated Amycolatopsis sp. HCa1. Planta Medica 2012, 78(10): 988-994.  

  4.  Z. K. Guo, T. Yan, Y. Guo, Y. C. Song, R. H. Jiao, R. X. Tan, H. M. Ge*. p-Terphenyl and diterpenoid metabolites from endophytic Aspergillus sp. YXf3. J. Nat. Prod. 2012, 75(1), 15−21.  


2011

  1.  H. Xu, N. Jiang, Y. Guo, R. H. Jiao, J. T. Cui, Y. C. Song, R. X. Tan. Fully substituted unsaturated lactones from endophytic Myrothecium sp. J. Asian Nat. Prod. Res. 2011, 13(11), 1003–1007.

  2.  H. M. Ge, W. Yan, Z. K. Guo, Q. Luo, R. Feng, L. Y. Zang, Y. Shen, R. H. Jiao, Q. Xu, Ren Xiang Tan*. Precursor-directed Q1 fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. Chem. Commun.2011, 47(8), 2321–2323.


  1.  J. Zhang, H. M. Ge, R. H. Jiao, J. Li, H. Peng, Y. R. Wang, J. H. Wu, Y. C. Song, R. X. Tan*. Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. Planta Med. 2010, 7616, 1910–1914.  



  1.  Hui Ming Ge, Rui Hua Jiao, Yu Fei Zhang, Jie Zhang, Yu Rong Wang, Ren Xiang Tan. Cytotoxicity and Phytotoxicity of Trichothecene Macrolides from Myrothecium gramminum. Planta Medica 2009, 753: 227–229.  


  1. Jiao R. H., Xu S., Liu J. Y., Tan R. X.  Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Organic Letters 2006, 8(25): 5705-5708.IF=4.082

  2.  Li Shen, Rui H. Jiao, Yong H. Ye, Xiao T. Wang, Chen Xu, Yong C. Song, Hai L. Zhu, and Ren X. Tan. Absolute configuration of new cytotoxic and other bioactive trichothecene macrolides. Chemistry, A European journal 2006,12: 5596-5602.Rui H. Jiao, Hui M. Ge, Da H. Shi, Ren X. Tan. An Apigenin-Derived Xanthine Oxidase Inhibitor from Palhinhaea cernua.Journal of natural Products 2006, 69(7): 1089-1091.   

  3. F. W. Wang, R. H. Jiao, A. B. Cheng, Y. C. Song. Antimicrobial potentials of endophytic fungi residing in Quercus variabilis. World Journal of Microbiology & Biotechnology2007, 23 (1): 79-83.   

  4.  Feng-Wu Wang, Rui-Hua Jiao, Ren-Xiang Tan, Hai-Liang Zhu and Edward R. T. Tiekink. 1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methylprop-1-enyl) -5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione. Acta Crystallographica Section E. 2006, E62: o1375–o1377.

  5. Wen-Zheng Ju, Rui-Hua Jiao, Ping Cao and Rui-Qin Fang. Bis(2-aminopyridine)dibenzoatocobalt(II). Acta Crystallographica Section E. 2006, E62: m1012–m1013.  


主持在研项目

1、海洋微生物先导化合物的生物合成调控与产率优化,国家863计划海洋技术领域主题项目

2、海洋共生微生物先导化合物的发现与优化,国家863计划海洋技术领域主题项目(共同主持)

3、共生真菌产生的新型抗病原菌化合物的发现与作用机制研究,江苏省基金面上项目


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